Placebo vs. 600mg vs. 900mg New Formulation Miricorilant
It looks like full-on NASH not just NAFLD patients, and thus many (most?) will be obese. I am expecting successful changes in the liver fat content and ELF scores. Miricorilant should improve the metabolic metrics including weight. By itself, weight and fat reduction should strongly move the needle.
Reviewers want drugs that improve the liver independent of weight reduction. In animal models, miricorilant reduces appetite and improves metrics independent of weight. It also preferentially removes pathogenic white fat from the liver.
Nevertheless, if I was a clinician, I would desire both characteristics, but especially want my patients to lose weight. It is probably the best single thing that can be done for many NASH patients; the condition can quickly improve with immediate weight / fat reduction. NASH Clinical Trial Listing