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DEC 2019..active RA may increase the risk of CVD even after initial CAD diagnosis and treatment...Dual diagnosis in great need..all concerned about diseases should be rooting for tilmanocept success sooner than later!!!This is a Dec 2019 study out of Denmark on RA and CAD link studying
358 patients, furthering the confirmation of prior studies on RA
and CVD linkage and progression of CVD in RA even after CV treatment,.
Study also notes RA patients are under diagnosed and under treated for
CVD. From my novice perspective both points continue further supporting the linkage and need for a dual diagnostics and follow up process. Original research Risk of major adverse cardiovascular events among patients with rheumatoid arthritis after initial CT-based diagnosis and treatment
Received 29 september 2019 revised 12 December 2019 accepted 15 December 2019 Annette de Thurah ,1,2 Ina Trolle Andersen,3 Andreas Bugge Tinggaard,4Anders Hammerich Riis,3 Josephine Therkildsen,4 Hans Erik Bøtker,2,5Morthen Bøttcher,4 Ellen-Margrethe Hauge1,2
" Results among 42,257 (CVD) patients, referred between 2008 and 2016, we identified 358 (0.8%) with ra. an increased risk was seen in ra compared with non- ra (adjusted hr 1.35, 95% ci 0.93 to 1.96). among patients who had received flare treatment more than once prior to cardiac cT the adjusted hr 1.80 (95% ci 1.08 to 3.00), and among patients with seropositive ra the adjusted hr 1.42 (95% ci 0.93 to 2.16). Conclusion in patients referred to cardiac cT due to chest pain, we found a trend of an association between ra and the combined primary outcome, supporting that ra per se, but in particular seropositive and active ra, may increase the risk of caD even after initial caD diagnosis and treatment.. ...
Finally, it has been shown that patients with RA are generally underdiagnosed, and undertreated for their CVD.3 In this cohort, all patients have, however, been seen by a cardiologist, and subsequently treated according to their CAD diagnosis, making this potential misclassification unlikely.
Conclusion We found a trend of an association between RA and the development of CVD in this cohort of patients with an a priori low-intermediate risk of CAD, even after initial diagnosis and medical treatment, supporting that RA per se, and in particular seropositive and active RA, may increase the risk of CAD even after initial CAD diagnosis and treat-ment.
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