CONCLUSION...SLNB is currently deemed considerably valuable in the management of patients with melanoma, especially in case of intermediate-thickness melanoma. The study of the lym-phatic flow rate may yield additional predictive information in terms of lymphogenic metastatic spread. 99mTc-Tilmanocept seems to be the most promising alternative to radiocolloids for melanoma located in certain anatomical regions; further large investigational studies are warranted to confirm the limited evidence available in the literature. The use of SPECT/CT improves the diagnostic accuracy in the identification of the SLN. New intraoperative tools for the identification of SLN, such as portable gamma-cameras, freehand SPECT navigation systems and hybrid intraopera-tive imaging techniques, may be helpful for the surgeons; however, further technical validation is warranted