I think Yellow Fever is the greater world threat right now since it is mosquito driven, is in more geographical areas, and is seen in the US. Isn't Galidesivir eligible for the Animal Rule from safety testing, and it gave very positive survival results in Macaques, as I recall?
“These results for the IV route of administration of galidesivir, which build on a previous successful Phase 1 trial for the IM route, support its continued development for serious and life-threatening infections from RNA viruses. We appreciate the government’s continued financial support for and collaboration on the program as we advance galidesivir into a trial in patients with Yellow Fever in Brazil during the upcoming Yellow Fever season,” said Dr. William Sheridan, chief medical officer of BioCryst.
The effectiveness of Galidesivir has been studied in animal models for at least 7 years,
Yellow fever is a very serious world threat.
Biocryst's response is lackadaisical at best in this case!