So what about the animal rule......................... | BCRX Message Board Posts

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Msg  12350 of 12373  at  9/10/2020 1:48:59 PM  by


So what about the animal rule.........................

 Remember this from June 6th..............
 Zika Study Details
In the Zika virus study of galidesivir, 70 Rhesus macaques were studied with different routes of infection, different doses of galidesivir, and galidesivir treatment initiated at different time points after infection. Endpoints included Zika virus RNA quantity in plasma, saliva, urine, and cerebrospinal fluid (CSF), and a variety of immunologic measurements, including antibody seroconversion to Zika virus. Galidesivir was safe and showed robust antiviral activity at all stages of Zika infection and at multiple different doses. Zika-infected animals that were treated with galidesivir developed an immune response to Zika that was protective against subsequent Zika re-challenge.

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