"Which brings us back to the key question; when is the company going to submit a file?"
If you are specifically referring to the FDA, I'll hazard a guess at 4 or 5 years time.
I don't think you fully appreciate their existing filing strategy. An FDA filing is clearly not seen as a priority. When they do go to the FDA, they will want to be armed with more post-marketing real-world data derived from the priority jurisdictions.