Gary, you didn't read my comment. EVERY article in the NEJM is listed on the cover, it is just a table of contents so it really doesn't matter.
What does matter is that the results get published in a journal that is respected and widely read by the target audience. NEJM is widely read, but I am not sure it reaches the target audience as well as some others. Ditto for Lancet.
Regardless, if the results appear in a credible journal and they are as robust as you hope them to be then it will be big news.