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Msg  1609 of 1620  at  2/18/2020 9:00:58 AM  by

auh2oman


Tilsotolimod - New Trial ...

Intratumoral Tilsotolimod, a TLR-9 Agonist, Together With Intratumoral Ipilimumab and Intravenous Nivolumab in Patients With Advanced Cancers

2020-02-17 18:20:22 | BioPortfolio

Summary

Open label, phase Ib study of intratumoral tilsotolimod in combination with intratumoral ipilimumab and intravenous nivolumab.

The trial will be divided into two parts:

PART A:

the first part will assess the safety of two regimen and will recruit patients with all types of injectable solid malignancies

PART B:

the second part will include 3 expansion cohorts of 15 patients:

- B1: anti-PD-1 refractory advanced NSCLC cohort

- B2: anti-PD-1 refractory advanced melanoma cohort

- B3: immunotherapy naïve microsatellite stable colorectal cancer (MSS CRC) cohort

Study Design

Conditions

Advanced Cancer

Intervention

Ipilimumab, Nivolumab, Tilsotolimod

Location

Gustave Roussy
Villejuif
Val De Marne
France
94805

Status

Not yet recruiting

Source

Gustave Roussy, Cancer Campus, Grand Paris

 
 
 https://www.bioportfolio.com/resources/trial/264395/Intratumoral-Tilsotolimod-a-TLR-9-Agonist-Together-With-Intratumoral-Ipilimumab-and-Intravenous.html
 
 
 https://clinicaltrials.gov/ct2/show/NCT04270864
 
 
 


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Replies
Msg # Subject Author Recs Date Posted
1610 Re: Tilsotolimod - New Trial ... vorlon1966 1 2/24/2020 8:14:34 PM
1613 Re: Tilsotolimod - New Trial ... vorlon1966 1 2/24/2020 9:01:48 PM






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