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Msg  1609 of 1650  at  2/18/2020 9:00:58 AM  by


Tilsotolimod - New Trial ...

Intratumoral Tilsotolimod, a TLR-9 Agonist, Together With Intratumoral Ipilimumab and Intravenous Nivolumab in Patients With Advanced Cancers

2020-02-17 18:20:22 | BioPortfolio


Open label, phase Ib study of intratumoral tilsotolimod in combination with intratumoral ipilimumab and intravenous nivolumab.

The trial will be divided into two parts:


the first part will assess the safety of two regimen and will recruit patients with all types of injectable solid malignancies


the second part will include 3 expansion cohorts of 15 patients:

- B1: anti-PD-1 refractory advanced NSCLC cohort

- B2: anti-PD-1 refractory advanced melanoma cohort

- B3: immunotherapy naïve microsatellite stable colorectal cancer (MSS CRC) cohort

Study Design


Advanced Cancer


Ipilimumab, Nivolumab, Tilsotolimod


Gustave Roussy
Val De Marne


Not yet recruiting


Gustave Roussy, Cancer Campus, Grand Paris


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Msg # Subject Author Recs Date Posted
1610 Re: Tilsotolimod - New Trial ... vorlon1966 1 2/24/2020 8:14:34 PM
1613 Re: Tilsotolimod - New Trial ... vorlon1966 1 2/24/2020 9:01:48 PM

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