Articles like these help us see just how complex the to and fro of the immune system is in fighting tumors without creating toxicity and autoimmune side effects. Too much of a good thing can create unacceptable toxicity or counteregulatory tumor promotion while too little results in poor efficacy. As the combination therapies evolve this overview and others help with the understanding of why certain strategies are chosen. This article is very light on TLR but provides a good reference for most of the pathway players.
Immune interactions involving antigen presenting cells or tumor cells, T cells, and tumor microenvironment