GILD have a synthetic biology platform called synNotch . Using it T and NK cells can locally express a range of payloads, including pro-inflammatory cytokines and different (bi-specific) mAbs. They can also produce adjuvants that would stimulate an innate immune response, thus potentially augmenting any host-mediated immune response. Given the flexibility of this, it may be possible to deliver many different payloads, 'customised' for a particular type. Then, they could add genetic engineering (say using SGMO's ZFNs) on top of this. So I fail to see how something like a vaccine could ever 'trump' any of this?