Formula for success? | IDRA Message Board Posts

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Msg  1513 of 1524  at  8/17/2019 5:29:57 PM  by

clsm

The following message was updated on 8/17/2019 5:30:35 PM.

 In response to msg 1509 by  vorlon1966
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Re: Formula for success?

GILD have a synthetic biology platform called synNotch [1]. Using it T and NK cells can locally express a range of payloads, including pro-inflammatory cytokines and different (bi-specific) mAbs. They can also produce adjuvants that would stimulate an innate immune response, thus potentially augmenting any host-mediated immune response. Given the flexibility of this, it may be possible to deliver many different payloads, 'customised' for a particular type. Then, they could add genetic engineering (say using SGMO's ZFNs) on top of this. So I fail to see how something like a vaccine could ever 'trump' any of this?
 
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Msg # Subject Author Recs Date Posted
1514 Re: Formula for success? vorlon1966 0 8/19/2019 12:17:44 PM


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