Changes in Study Status and Arms and Interventions With Illuminate-301 ...why combo with IPI good i | IDRA Message Board Posts

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Msg  1459 of 1609  at  6/24/2019 7:28:12 PM  by

vorlon1966

The following message was updated on 6/24/2019 7:39:16 PM.

 In response to msg 1457 by  vorlon1966
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Re: Changes in Study Status and Arms and Interventions With Illuminate-301 ...why combo with IPI good idea

Why you want IPI in combo with IMO 2025:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317697/

“Conclusions

The CTLA-4 pathway is a critical regulator of T cell responses to tissues. The sharing of ligands with the stimulatory receptor CD28 establishes a rheostat, capable of tuning T cell responses. Accordingly, decreasing CTLA-4 function by antibody blockade, or in CTLA-4 genetic disorders, increases the availability of ligands for CD28 permitting the activation of potentially self-reactive T cells and altering Treg homeostasis. Furthermore, the high level expression of CTLA-4 on Treg and the emerging cell biology of this pathway continue to offer opportunities to stimulate or inhibit T cell responses.”

Further evidence in the paper that IPI is a Treg inhibitor....whooo-ah!

https://www.youtube.com/watch?v=V9kQBz9azy8


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Msg # Subject Author Recs Date Posted
1460 Re: Changes in Study Status and Arms and Interventions With Illuminate-301 ...why combo with IPI good idea cert77 0 6/24/2019 8:58:04 PM






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