Acadia is now only 9.5% of my portfolio now.  I keep a spreadsheet with a column that shows the percent of holdings for each stock.  This gets updated automatically based on the stock prices.  Lucky for me I stuck with keeping my Acadia investment to no more than 20% of my portfolio at the time of purchase.  Of course, that number changes as my stocks go up and down.  This is what saved me on Acadia.

 

I also lucked out on ITCI.  My average buy-in on that is $15.51.  Even if you average in my ITCI gains, my total returns for Biotech over the years were below-par considering the risk.   Here are my returns for me biotechs:

NERV - 0% - I sold out at break-even after being up significantly.

ITCI  193% (gain)

ACAD  -36% (loss)

NERV - Breakeven

 

My total gain from all three is only 29%.  When considering the length of time I have held these investments it has been a return well below what the S&P has done over the same period of time.

 

My only gain with ITCI was almost pure luck as they were not expected to get approval.  Once I dump ITCI and ACAD I will likely keep my biotech stocks to a minimum in my portfolio.  I am looking for an exit for both.