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Bristol-Myers Squibb Co.
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Building IP: BMY Patent Appl"PRODRUGGABLE ANTIBODIES, PRODRUGS THEREOF, AND METHODS..PRODRUGGABLE ANTIBODIES, PRODRUGS THEREOF, AND METHODS OF USE AND MAKINGDOCUMENT IDUS 20230295346 A1 DATE PUBLISHED2023-09-21 INVENTOR INFORMATION NAMECITYSTATEZIP CODECOUNTRYKrystek, JR.; Stanley R. Ringoes NJ N/A US Zhang; Yong West Windsor NJ N/A US Vite; Gregory D. Titusville NJ N/A US Rajpal; Arvind San Francisco CA N/A US Rao-Naik; Chetana Walnut Creek CA N/A US Morin; Paul E. Pennington NJ N/A US Srinivasan; Mohan Cupertino CA N/A US Lin; Zheng North Wales PA N/A US Lafont; Virginie Lawrence Township NJ N/A US Pritsker; Alla Morganville NJ N/A US APPLICANT INFORMATION NAME BRISTOL -MYERS SQUIBB COMPANY CITY Princeton STATE NJ ZIP CODE N/A COUNTRY US AUTHORITY N/A TYPE assignee APPLICATION NO18/180998 DATE FILED2023-03-09 DOMESTIC PRIORITY (CONTINUITY DATA)parent US continuation 16103654 20180814 parent-grant-document US 11623965 child US 18180998 us-provisional-application US 62546252 20170816 CPC CURRENT TYPECPCDATEAbstractA prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen. |
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