Re: T-VEC + Permbrolizumab data in liver cancer
Not surprising. Tvec causes apoptosis which doesnít really release cancer specific antigens for bystander effect.....no matter what they may claim. Itís not a good primer for the immune system. PV-10 causes autolysis first followed by quick attempt at apoptosis.....then autolysis to necrosis takes over faster than apoptosis. In solid tumor ablation by PV-10 injection you end up seeing byproducts of autolysis, autophagy, apoptosis, and necrosis. In realty PV-10 trips all these mechanisms resulting in cascade byproducts in all paths. Those researchers of PV-10 find the byproducts they are looking for. One researcher may say PV-10 causes apoptosis...and for a snapshot in time it does. But in reality, autolysis spills out acidic hydrolyses of the lysosomes. That starts cell death cascade. The cancer cell then kicks in apoptosis to try to self destruct without releasing antigens for normal cell death. However, autolysis continues and overcomes apoptosis path and results in necrosis which blows apart the micelle bilayer cell membrane releasing the cancer specific antigens in bits not tied to normal antigens. The immune system can now see bits of cancer specific antigens without being fooled by normal antigens telling the immune system the cell was normal.