Goolsbee at Antisense 40 mos. ago | SRPT Message Board Posts


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Msg  14396 of 14405  at  10/19/2021 1:16:46 PM  by

schmiggins


Goolsbee at Antisense 40 mos. ago

https://stockhead.com.au/health/could-antisense-be-the-next-multi-billion-duchenne-muscular-dystrophy-biotech/

"The data from a Phase 1/2a trail reported by Sarepta suggests that its experimental gene therapy may slow the disease.

Antisense director William Goolsbee believes Antisenses treatment may make that Sarepta drug, that is already on the market for DMD, work even better.

Thats because Mr Goolsbee came from Sarepta where he served as a non-executive director until 2016....

"But what Antisense is doing is quite different to the Sarepta drug.

There we had a disease modifying drug that modified protein expression in the body and changed the course of the disease, Mr Goolsbee said.

But in a vicious circle, while the Sarepta drug may slow the progression of the disease it cant stop the disease-created inflammation that keeps attacking the muscle.

The Antisense treatment is designed to treat the inflammation that exacerbates muscle fibre damage.

This can be managed by using cortico-steroids but these come with a whole range of side effects including excessive weight gain precisely the wrong thing for boys who already have limited movement.

What we want to do is add our treatment ATL1102 on top of that drug and eliminate a substantial portion of continued muscle degeneration, so whatever the period of ambulation is for that boy would be longer years is our expectation, Mr Goolsbee said.

We can almost create a position of stasis of the disease.


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Msg # Subject Author Recs Date Posted
14397 Re: Goolsbee at Antisense 40 mos. ago schmiggins 0 10/19/2021 1:33:23 PM


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