Precision screening for familial hypercholesterolemia-capturing the missing 90% | ARWR Message Board Posts

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Msg  10070 of 10107  at  10/21/2019 12:23:56 PM  by

Aspector


Precision screening for familial hypercholesterolemia-capturing the missing 90%

www.sciencedirect.com/science/article/pii/S2589750019301505?via=ihub

Background
Cardiovascular outcomes for people with familial hypercholesterolaemia can be improved with diagnosis and medical management. However, 90% of individuals with familial hypercholesterolaemia remain undiagnosed in the USA. We aimed to accelerate early diagnosis and timely intervention for more than 13 million undiagnosed individuals with familial hypercholesterolaemia at high risk for early heart attacks and strokes by applying machine learning to large health-care encounter datasets.

"People born with familial hypercholesterolemia develop cardiovascular damage by puberty, often culminating in early heart attacks or the need for surgery as young or middle-aged adults," said Katherine Wilemon, founder and CEO of the FH Foundation and study co-author. "Since diagnosis of this deadly but treatable condition has stalled in the American medical system, the FH Foundation harnessed artificial intelligence and big data to accelerate identification of those most likely to have FH."


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