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ACC2020 - ASSOCIATION OF HDL SUBCLASSES WITH BASELINE CORONARY PLAQUE BURDEN BY CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY (CCTA) FROM EVAPORATE (EFFECT OF VASCEPA ON IMPROVING CORONARY ATHEROSCLEROSIS IN PEOPLE WITH HIGH TRIGLYCERIDES TAKING STATIN THERAPY
1158-161 / 161 - ASSOCIATION OF HDL SUBCLASSES WITH BASELINE CORONARY PLAQUE BURDEN BY CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY (CCTA) FROM EVAPORATE (EFFECT OF VASCEPA ON IMPROVING CORONARY ATHEROSCLEROSIS IN PEOPLE WITH HIGH TRIGLYCERIDES TAKING STATIN THERAPY) TRIAL
Suvasini Lakshmanan, Chandana Shekar, Suraj Dahal, Afiachukwu Onuegbu, April Kinninger, Andrew Cai, Divya Birudaraju, Lavanya Cherukuri, Ilana Golub, Vahid Rezvanizadeh, Christopher Dailing, Ferdinand Flores, Sajad Hamal, Sion K. Roy, John Nelson, Matthew J. Budoff, Lundquist Institute for Biomedical innovation, Torrance, CA, USA
Abstract
Background: HDL subclasses have been correlated with cardiovascular disease (CVD) risk. Different subpopulations of HDL particles mediate pathogenesis of coronary atherosclerosis by multiple pathways. Total Non-Calcified Plaque (TNCP) and Total Plaque (TP) volumes by CCTA are correlated with adverse cardiovascular outcomes. Methods: We examined association of baseline coronary plaque volumes on CCTA with serum HDL subclass levels in 67 subjects enrolled in EVAPORATE. Coronary Plaque on CCTA was identified and volumes were measured using semi-automated plaque analysis software (Qangio) HDL subclasses were quantified using Boston Heart HDL Map test. Multivariate linear regression was performed to assess the relationship. Results: After adjustment for suitable confounders, Alpha 1 HDL levels were associated with lower log TNCP ( βετα -0.09 SE 0.02 P .0003) and log TP (βετα -0.107 SE .03 P .0004) volumes in diabetics. Alpha 2 HDL levels were associated with lower log TP (βετα -0.04 SE 0.02 P .032) volume in all subjects. (Table 1) Conclusion: This study shows for the first time that serum alpha 1 and alpha 2 HDL levels in patients on statin therapy with residually elevated triglycerides are inversely associated with clinically significant TP and TNCP volumes, measured by CCTA. Future research can help validate this association for diagnostic and therapeutic strategies for CVD.