Also looking for insight into direction CYDY is taking wrt HIV - found this | CYDY Message Board Posts


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Msg  14731 of 14800  at  5/26/2023 10:54:50 AM  by

rubraquercus

The following message was updated on 5/26/2023 11:00:11 AM.

 In response to msg 14728 by  Beldar
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Re: Also looking for insight into direction CYDY is taking wrt HIV - found this

 
 Webb was published on the same in late 2019
 
A CCR5-blocking antibody for HIV pre-exposure prophylaxis Xiao Lan Chang1 ,Gabriella Webb1 , Jason S. Reed1 , Helen L. Wu1 , Nicole Burnett2 , Miranda Fischer2 , Cassandra Moats2 , Michael K. Axthelm1,2, Jeremy Smedley1,2, Nader Pourhassen3 , Justin M. Greene1 , Jonah B. Sacha1,2 Affiliated Institutions: 1 VGTI and 2 ONPRC, Oregon Health & Science University, Beaverton, OR, 97006, USA 3 CytoDyn, Inc. In the absence of a prophylactic vaccine, the use of antiretroviral medications as pre-exposure prophylaxis (PrEP) to prevent HIV acquisition by uninfected individuals is a promising approach to slowing the epidemic. Unfortunately, negative side effects, viral resistance, and lack of regimen adherence severely limit PrEP efficacy. Thus, new approaches are urgently needed. The use of the CCR5 coreceptor by mucosally transmitted virus, together with the high resistance to sexually transmitted HIV observed in CCR5D32 homozygous individuals, indicates that CCR5 blocking reagents might be effective novel PrEP agents. Leronlimab, formerly PRO140, is a CCR5-specific humanized IgG4 monoclonal antibody currently in clinical trials for use as HIV monotherapy 
 
 
 


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