MIT tech review says Sangamo found BLC11A target crispr patent | SGMO Message Board Posts


Sangamo Therapeutics, Inc.

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Msg  177109 of 178390  at  12/7/2023 1:07:41 PM  by

gomasna


 In response to msg 177106 by  rynothekmife
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Re: MIT tech review says Sangamo found BLC11A target crispr patent

Great article, thanks for sharing!
 
Sangamo mentioned in this excerpt: 

Drug target

The switch had mostly been a matter of scientific curiosity. But now researchers at Harvard, and at a company they’d teamed with, Sangamo Biosciences, began to define a treatment. They peppered the enhancer with every possible damaging edit they could—“like a bunch of BBs,” says Bauer, who did the work at Harvard. Eventually, they found the perfect one: a single disruptive edit that would lower BCL11A by about 70%, and consequently allow fetal hemoglobin to increase.

but not here:
There are signs Orkin’s lab may have found a perfect edit—one that can’t be easily improved on. His institution, Boston Children’s Hospital, patented the discoveries, and later CRISPR Therapeutics and Vertex agreed to pay it for rights to use the edit. They’ll likely contribute royalties, too, once the treatment goes on sale. Orkin told me he thinks the companies tried to develop an alternative—a different, nearby edit—but hadn’t been successful. “They tried to find a better [one] but they couldn’t,” says Orkin. “We have the whole thing.”  


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Replies
Msg # Subject Author Recs Date Posted
177110 Re: MIT tech review says Sangamo found BLC11A target crispr patent rynothekmife 3 12/7/2023 1:13:31 PM
177112 Re: MIT tech review says Sangamo found BLC11A target crispr patent gomasna 0 12/7/2023 1:19:40 PM
177113 Re: MIT tech review says Sangamo found BLC11A target crispr patent gg100 0 12/7/2023 3:46:26 PM




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