Building IP: SGMO Patent Grant "Engineered Target Specific Base Editors" | SGMO Message Board Posts


Sangamo Therapeutics, Inc.

  SGMO website

SGMO   /  Message Board  /  Read Message

 

 






Keyword
Subject
Between
and
Rec'd By
Authored By
Minimum Recs
  
Previous Message  Next Message    Post Message    Post a Reply return to message boardtop of board
Msg  177091 of 178609  at  12/5/2023 1:42:13 PM  by

dachmeister4u

The following message was updated on 12/5/2023 1:52:40 PM.

 In response to msg 177089 by  JBWIN
view thread

Re: Building IP: SGMO Patent Grant "Engineered Target Specific Base Editors"

   
I have alway appreciated your efforts in keeping track of the IP, JBWIN,  Deep insights into gene engineering is very difficult for me to grasp and therefore, I am prone to creating massive misinterpretations.   It is natural then, to simply keep looking ahead toward the results -- trial data and approvals.
 
In section 34, the following copy and paste sections sure bubble up to my small brain that this patent includes methods for increasing precision for editing without a double strand break ...  across the entire spectrum of ZFN, TALE and variants of Crispr/CAS (beyond Cas9):
 
>>  In some embodiments, fusion molecules comprising a DNA binding domain and an engineered FokI or homologue thereof cleavage half-domain as described herein that produce an artificial nuclease are provided. In some embodiments, the DNA-binding domain of the fusion molecule is a zinc finger binding domain (for example, an engineered zinc finger binding domain, ZFP). In some embodiments, the one or more of the zinc fingers are linked together using linkers identified using the methods disclosed in Paschon, et al., supra. In some embodiments, the DNA-binding domain is a TALE DNA-binding domain (TALE). Ithe DNA binding domain comprises a ZFP fused to a catalytically inactive Cas (dCas) protein. <<
 
At some point in the future of Sangamo, the learnings and IP from 23 years may result in a moat so wide and deep that all GE roads might need to pass through Brisbane, FOR ALL I KNOW in my half-baked thinking. 
 
Makes me wonder who at Sangamo has either authored and/or maintains an internal (to the company only) program that represents the entire domain of all awarded patents, organized by classifications of function and .. also shows the branches of advances within each classification as the research dove deeper over time:  a concise assessment, describing the improvement to each step along the progression.   Sandy says to bct, "We will win." That is a bold statement.  Is there a PhD (GenEng) in the house that can slap me as stupid ... please?
 
 
 
 
 


     e-mail to a friend      printer-friendly     add to library      
|  
Recs: 13  
   Views: 0 []
Previous Message  Next Message    Post Message    Post a Reply return to message boardtop of board

Replies
Msg # Subject Author Recs Date Posted
177092 Re: Building IP: SGMO Patent Grant "Engineered Target Specific Base Editors" nocashonhand 1 12/5/2023 2:33:20 PM
177098 Re: Building IP: SGMO Patent Grant "Engineered Target Specific Base Editors" TECH32 1 12/7/2023 7:08:20 AM




Financial Market Data provided by
.
Loading...