got this in my mail, something i kinda half understand and thought others might be interested in where current research is at.
something i have a huge personal interest in and have been totally reoriented with respect to the disease since begininig to understand the role of different microglial states.
thought it might help others who find the papers impenetrable. like me.
i see this as the next target for gene therapies where the abiity to use the specific tropism of the rAAV designed by DNA shuffling techniques to target only specific cell types, specifically the microglial cells or astrocytes that orient and corral them to focus on the amyloid beta plaques. using the TREM2 signal.