We may have different views on the need for partnerships. I have been in Sangamo since 2007 and have seen them try to go alone on DN 3-4 times, HIV and MPS 1-2. They always waited for the #&§+& inflexion points before partnering those and they all ended up in fiascos. As 7-8 other programs. But they partnered Beta Thal and Sickle Cell, Huntington, Hemo A etc and got the research expensives paid by their partners. The only reason we did not end up as a penny stock earlier. It has taken long for Beta Thal and Sickle Cell but the chance of not ending up in another fiasco is pretty good. We hardly could have waited so many years without their financing.
Pfizer has done an excellent job with Hemo A and SM has said on several occasions how much they have learned from that trial and how they have adapted it for Fabry.
The same way we have learned form Beta Thal, Huntington etc. We can use that knowledge for our next trials. That is a nice side effect apart from the fact that it helped us staying afloat.
So now about the talk of partnerships. Since there hardly is any way for a 1 BB company to finance and successfully get products for CNS and Treg to the market on
their own I think we Need partnerships. We don´t have to partner the whole platform but 1-2 indications from each area. Why should we not do a partnership on MS or Crohn´s or Diabetes for Immunology and learn from the partnerships (like we learned from Hemo A and Beta Thal) , have a better financial situation and for all have a better chance of really getting those products to the market ? The same can be said for CNS diseases. Partner Alzhiemer (like they already said they will do) and 1 or 2 other indications and learn from it !! Since our pipeline is INFINITE, as has been said so many times we have enough opportunities to go alone ONCE WE HAVE LEARNED HOW IT WORKS.
I don´t care about day dreaming about 100 BB market cap with very low odds of ever achieving it. Make sure we learn how to do it, get a market cap of 10 BB and then aim for 50 + with our infinite pipe line. High chances of success is more important than the high numbers. We will anyway be bought out on our way to those dream numbers.
So that is the reason I want to see partnerships for a few indications as soon as possible, when our pipe line is infinite, waiting for another inflexion point that maybe never will materialize on our own is useless. We just need the highest best odds for the fastest success .Competition dosen´t sleep either.