this is the most current review jan 2019, jude samulski is founder of Asklepos and Bamboo and this paper refers back to the previous paper but is more 'generalized' in that it covers other topics, and especially interesting is the current use of cryoelectron microscopy to visulize the binding of the neutraling antibodies to the virion antigenic sites. another good paper,cannot remember if it was one i covered already,
Adeno-Associated Virus (AAV) Versus Immune Response
This cartoon describes two risks associated with adeno-associated virus (AAV) entrance in to a target cell. The innate immune repsonse is activated by TLR9 recognition of the externalization of the viral genome. This event is rapid and NF-kB will be activated resulting in proiinflammatory cytokine production. For the many virions that do not rapidly uncoat, a second risk exists—the slow degradation of the capsid. Proteasomes degradation of ubiquitinated AAV results in a small amount of capsid fragments being transported through the transporter associated with antigen processing (TAP), into the endoplasmic reticulum (ER), and innevitable attachment to major histocompatibility complex (MHC) class I molecules. These peptides will be displayed on the cell surface and eventually recognized by cytotoxic T cells.