SB gave a strange a reply to re-dosing at the ASM as it runs counter to a lot of the assumptions I've held on AAV redosing.
Someone asked a question about Treg-enabled redosing and SB replied that there was "nothing preventing re-dosing today" even without Tregs.
I was going to ask for clarification but the conversation moved on quickly from there so the opportunity was lost.
I'm not sure how this is possible unless:
A) the current dosing isn't generating an immune response (unlikely given size of dose)
B) there is another method for redosing using legacy methods (ie steroids)
C) SB was confused and was thinking about cell therapy redosing rather than viral redosing