Trying to wrap my head around the potential re-administration of AAV with chimeric AAV | SGMO Message Board Posts

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Msg  128461 of 133796  at  6/19/2019 12:15:57 PM  by

MaxPowerNGS


 In response to msg 128460 by  GAGholder
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Re: Trying to wrap my head around the potential re-administration of AAV with chimeric AAV

 SB gave a strange a reply to re-dosing at the ASM as it runs counter to a lot of the assumptions I've held on AAV redosing.
 
Someone asked a question about Treg-enabled redosing and SB replied that there was "nothing preventing re-dosing today" even without Tregs.
 
I was going to ask for clarification but the conversation moved on quickly from there so the opportunity was lost.
 
I'm not sure how this is possible unless:
A) the current dosing isn't generating an immune response (unlikely given size of dose)
B) there is another method for redosing using legacy methods (ie steroids)
C) SB was confused and was thinking about cell therapy redosing rather than viral redosing 


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Replies
Msg # Subject Author Recs Date Posted
128464 Re: Trying to wrap my head around the potential re-administration of AAV with chimeric AAV GAGholder 0 6/19/2019 1:02:07 PM
128475 Re: Trying to wrap my head around the potential re-administration of AAV with chimeric AAV bct1192 15 6/19/2019 1:55:47 PM


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