|
|
|
|
||
Re: Prior vaccine = more susceptibility....(first I think the author's hypothesis of prior mandatory coronovrius vaccination causing high mortality in Wuhan is bollocks .... but there is some interesting science on the SARS and MERS vaccines and potential for TH2 hypersensitivity .... as is always the case, any good conspiracy has some truth fragments in there to give it traction). So ..... >> There a couple of observations in mice of SARS and/or MERS vaccines leading to enhanced lung eosinophil inflammatory response, which can be pathological. This has come up before in discussion with RSV and the old failed inactivated RSV trials from decades ago (as I recall, and some related studies, as I recall) The SARS/MERS work appears solid. In mouse models, and NHP models, vaccines induced protection ... but they were also observed to precipitate a TH2-type hypersensitivity involving eosinophils. The was most noticeable in inactivated whole virus or multi-antigen VLPs, but was also observed in insect cell recombinant spike protein candidates (Protein Sciences). How this translates to protection versus hypersensitivity-pathology in humans using a recombinant spike NP ala NVAX is not particularly clear. Obviously candidates with NHP pathology would not move forward. The nature of the adjuvant has been explored some. Alum might be a problem. A peek at the ASO1 adjuvant (Matrix-M like perhaps) suggested it perhaps avoided the problem. There are some known unknowns here. An advantage of SUVs (NVAXs single recombinant antigen approach) is the potential to avoid some hypersensitive reactions. The more balanced response-driven my MM may also serve to diminish hypersensitivity. I read a lot about all of this back in the day, but I'm worn out on reading about NVAX stuff so the details are a bit blurry. |
return to message board, top of board |