Protein Vaccines have better and longer immune response in children vs mRNA | NVAX Message Board Posts


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Msg  125115 of 134076  at  5/3/2021 7:38:10 AM  by

searching4alpha

The following message was updated on 5/3/2021 7:38:46 AM.

 In response to msg 125108 by  sbiller1
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Re: Protein Vaccines have better and longer immune response in children vs mRNA

Great news, Highly recommend reading the paper. Red, Muddy, Henry, as always, look forward to comments you all may have. Its 4:30am here so Ill only pull out a few highlights.

Importantly the study was run by Moderna it seems!

A. Carfi, and D. Edwards are employees of Moderna Inc. and hold equities from the company.

Ill be pleasantly surprised if this result makes it anywhere near the general press. Too esoteric I think. But for us this is fantastic affirmation of what we know/suspect about key advantages of the NVAX vaccine, i.e., that they produce a better, longer lasting innume response. RA Capital is the type of group to get this for sure though.

We evaluated the capacity of plasma antibodies to block entry of SARS-CoV-2 into human cells using a RBD-ACE2 blocking assay at 1:10 and 1:40 plasma dilutions. Antibodies elicited by the mRNA-LNP vaccine completely blocked RBD-ACE2 interaction at week 6 at 1:10 and 1:40 dilutions. Until W14, >80% blocking was achieved at 1:10 dilution, dropping for some animals after W18 (Fig. 3A). The Protein+3M-052-SE vaccine induced antibodies that mediated 100% RBD-ACE2 blocking after the second immunization, even at 1:40 plasma dilution, and this response was maintained throughout the study in 5 of 8 animals (Fig. 3A, Fig. S4).

AND...as we know, higher titers mean longer protection...

At week 6, median infectious dose 80 (ID80) titers, a stringent neutralization measurement, reached 1,179 in mRNA-LNP and 13,687 in Protein+3M-052-SE animals (Fig. 3B). Consistent with normal contraction of immune responses, median ID80 neutralization titers decreased 1.3-fold and 2.6-fold from week 6 to week 8 in the mRNA-LNP and Protein+3M-052-SE group, respectively. However, at week 22, median ID80 titers remained higher (2.6-fold or 14.2-fold in the mRNA-LNP or Protein+3M-052-SE group, respectively) than after the first vaccination (week 4) (Fig. 3B). A bi-phasic antibody decline was modeled for both vaccines, estimating that mRNA-LNP vaccinees maintain a protective neutralizing Ab titer, estimated at a reciprocal dilution of 100, for approximately 46 weeks. Protein vaccine recipients sustain protective levels for approximately 74 weeks (Fig. S5).

Relative salivary IgG levels are even better...

RBD-specific salivary IgG from mRNA-LNP recipients peaked at a median of 16.6 ng RBD-specific IgG per g of total IgG at week 6 (Fig. 2C). In the Protein+3M-052-SE group, median salivary RBD-specific IgG peaked at 98.2 ng/g IgG after the second vaccination and remained detectable throughout the study (Fig.2B).


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Replies
Msg # Subject Author Recs Date Posted
125132 Re: Protein Vaccines have better and longer immune response in children vs mRNA wwilson_2003 1 5/3/2021 9:27:02 AM
125352 Re: Protein Vaccines have better and longer immune response in children vs mRNA henryed75 5 5/3/2021 5:25:34 PM


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