Portola Pharmaceuticals Presents New In Vitro Data | PTLA Message Board Posts

Portola Pharmaceuticals, Inc.

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Msg  6370 of 6389  at  7/8/2019 9:58:26 AM  by

erniewerner


 In response to msg 6369 by  jaznblues
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Re: Portola Pharmaceuticals Presents New In Vitro Data

"4F-PCCs did not appear to have an effect on the inhibition of thrombin generation by apixaban or rivaroxaban unless the Factor Xa inhibitor concentration was less than 75 ng/mL. "
 
To gage the potential impact this understanding may have on clinical treatment, one needs to know what a typical inhibitor concentration is for an X or E patient presenting with a bleed.
 
 
"Rivaroxaban measurements varied from 5 to 358 ng/ml, with a post-intake delay ranging from 9 to 38 h. At trough, estimated plasma concentrations were between 12 and 251 ng/ml (median value 94 ng/ml). Four patients had higher-than-expected rivaroxaban levels. Inadequate dose regimen, excessive alcohol consumption and lack of treatment reassessment were observed in several patients. Half of patients were taking ≥1 drug with potential pharmacokinetics interactions (e.g. amiodarone, diltiazem), while half of patients were taking ≥1 drug increasing the risk of bleeding. All 3 patients with available genotyping data and higher-than-expected rivaroxaban levels were heterozygous or homozygous mutated for the ABCB1 1236C > T, 2677G > T, 3435 C > T and rs4148738 single nucleotide polymorphisms (SNP)." 
 
 


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Msg # Subject Author Recs Date Posted
6372 Re: Portola Pharmaceuticals Presents New In Vitro Data tjinvest 5 7/8/2019 8:46:44 PM


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