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I think 543's 8mg is better at obtaining the 50% mark. But the PFE drug was the much better of the 2 JAKs at reaching the 90% score & that is where every AA patient is hoping to reach. But its difficult to compare these drugs because the PFE drug was given for the 1st 4 weeks at 4 times the dose given for the last 20 weeks. CNCE's 8mg would have to be given for the 1st 4 weeks at 32mg to make a similar comparison. I'm expecting 543's 12mg dose to have half its AA patients reach the 90% level. If it does then I doubt PFE's drug will be able to compete unless 543 shows a higher level of AEs. PFE's head start & superior marketing skills will help their JAK but it will have to overcome the fact only 1 out of every 4 of their patients reached a 90% reduction on SALT.