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Summary of Gulley's tweets after BAVA failureComment "Bavarian Nordic Prostvac fails and DSMC recommends discontinuation bavarian-nordic.com/investor/news/… sad for patients & @ChrisHeery @gulleyj1 :(" A "We need to both ignite (vaccine) & facilitate function (immune checkpoint etc.) of anti-tumor immune cells then we will see clear activity.🤞" Q "Have you also observed synergies between vaccine and radiation and/or chemo?" A"We have seen improve progression free survival with vaccine and radiation or vaccine and chemo versus standard care alone." Comment "The whole prostate cancer field and patients are behind you as you work toward developing better therapies!" A "Absolutely and resolutely will! Encouraging data emerging with combination therapy (vaccine & checkpoint inhibitors with PR and PSA decr) 🤞 Q" What would your top 3 best synergy candidates with vaccine" A "IMO it depends on what is going on in the tumor microenvironment. But PD(L)1 inhibition, IL-15, TGF-beta inhibition and IDOi would rank hi." In short Gulley mentions ALL ingredients in PSS combo except for Nk cells !!! |
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