Pgen will be going after 19 and ZIOP is a zero. | PGEN Message Board Posts


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Msg  45838 of 46453  at  9/26/2021 1:19:18 PM  by

clsm

The following message was updated on 9/26/2021 2:46:18 PM.

 In response to msg 44718 by  clsm
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Re: Pgen will be going after 19 and ZIOP is a zero.

New clinical data from CARsgen (impressive ORR) https://www.prnewswire.com/news-releases/appealing-data-of-carsgen-therapeutics-car-t-ct041-in-advanced-gastric-cancer-presented-at-esmo-301380054.html

They plan to test the same CAR (in patients with both metastatic gastric and pancreatic), but it will co-express IL-7 and CCL21. This should improve trafficking, infiltration, persistence, induce epitope spreading, have an anti-angiogenic effect and could reduce the need for LD chemo https://clincancerres.aacrjournals.org/content/26/20/5494


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