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Msg  42526 of 42565  at  1/13/2021 4:25:44 PM  by

clsm

The following message was updated on 1/13/2021 4:26:09 PM.

 In response to msg 42518 by  rubraquercus
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Re: An alternate theory

''Just reading that makes my head hurt. I can't imagine trying to build that complex set of edits and then looking for a patient sick enough to not care about getting such a wildly complex and likely highly toxic drug.''

Complex problems require complex solutions. As the edits are done to the CAR-T's, it would reduce toxicities along with costs when compared to other treatments that are given systemically. The payloads could be a problem, but both AUTL [1] and Refuge Bio [2] seem to have overcome this.

''Someone must think it looks good on paper because so far that is all there is.''

A single armoured (dnTGFB) CAR-T product is being tested in mCRPC. A PhII should start in Q4.

Refs:
1 https://cancerres.aacrjournals.org/content/80/16_Supplement/1070
2 https://jitc.bmj.com/content/8/Suppl_3/A458.2


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