For those of you who would like to take advantage of our Luck O' the Irish SALE but prefer not to make payments online, you are welcome to send us a check or money order in the amount of $114.12 for a 3-year AD-FREE Premium Service Bundle or $190.20 for a 5-year Bundle. Make checks or money orders payable in US funds to "Investor Village" and send to: Investor Village, P.O. Box 2958, Marrero, LA 70073.
As many of you know, we operate on the honor system around here. So, in closing out our Luck O' the Irish SALE, we wanted to advise those of you who plan to pay by check or money order that you can send a PM to Admin informing us of your intention. We will then upgrade your account for 7 days, allowing you to enjoy our ad-free premium service now and giving you a reasonable amount of time to get your payment in.
You are just now figuring this out? That's the purpose of inclusion of a co-stimulatory domain. First gen Car-T cells died off in days. 2nd Gen Car-T cells expand 1000x+ fold in vivo (hopefully). CD28 has a bigger initial impact, but 4-1BB has a greater lasting effect. Some Kymriah kids still have Car-T cells many years after infusion. Cooper was supposedly going to replace CD28 with 4-1BB, but never did.
Recent video about real world use. Neelapu talks about Emily Dumler's neurotoxicity at 33:30. Both are featured in a current national MDA advertising campaign.