"but high teens to $20's before approval is a bit of a stretch IMO."
Were you around when we got the first CRL?? Right before we got it, right before our PDUFA date, we had vaulted to over $18...which I would consider "high teens".
This time, the CRL PR came out earlier in the process, but we were rising quickly and still had a couple weeks to continue rising. High teens were a real possibility again, but we never got the chance.