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Comparison of Trulance vs. Linzess approved prescribing informationI sent this to my internist. Trulance appears to have a better safety profile and is easier/more flexible to administer. Though their labels unfortunately have similar warnings, Trulance actually has less frequent (5% any), severe (0.6%) diarrhea, see para 6.1 at https://www.trulance.com/prescribing-information.pdf) than does the more well- known Linzess (20% any, 2% severe, for 290 mcg dose), see para 6.1 at http://www.allergan.com/assets/pdf/linzess_pi). Also Trulance can be taken with or without food, while Linzess must be taken on an empty stomach, at least 30 minutes before the first meal of the day (see paras 2.2 of both prescribing information links) Trulance is marketed by a struggling biotech (Synergy Pharm.) having limited resources, while Linzess is marketed (heavily, with frequent DTC tv ads) by big pharma (Allergan/Ironwood), which is why most clinicians have not heard of Trulance. Trulance was just placed on Express Scripts 2019 National Preferred Formulary list. Trulance: https://www.trulance.com/ Linzess: https://www.linzess.com/?guid=sem_goo_43700033057502898 |
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