I知 going to pop in here with curious updates on PVCT | ZIOP Message Board Posts

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Msg  114854 of 115224  at  9/25/2020 8:26:52 PM  by

vorlon1966

The following message was updated on 9/25/2020 8:36:34 PM.

I知 going to pop in here with curious updates on PVCT

Just going to point this out. In a P1 stage IV melanoma combo study subset of patients of PV-10/Keytruda where all lesions were injected. 75% complete response and 81% ORR. Now a 24 patient cohort is undergoing recruitment of stage III in-transit mets where all lesions will be injected with PV-10 prior to addition of systemic Keytruda.

Preclinical trials underway of oral systemic PV-10 in addition to injected PV-10 because Poetic out of Calgary is showing preclinical efficacy of oral PV-10 in child leukemia. PV-10 going into systemic application research in addition to intralesional injections.

I have postulated based upon Dr. Kruger痴 psoriasis research with PH-10...,a topical diluted form of PV-10...that showed an ability to reset over 500 psoriasis genes back to normal...and block IL-17 and IL-23....and thus blocks the IL-6 cascade...,that this portends an ability for systemic RB to be a Treg blockade. In addition to possibly become a CTLA4 blockade like IPI (Yervoy by BMY) it could also portend efficacy in colon cancer....without IPI toxicity or cost. It痴 being researched now by several independent research firms besides Poetic. Something to keep an eye on...because if true...it changes everything.

Do not just believe my post...do your own research.


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Replies
Msg # Subject Author Recs Date Posted
114855 Re: I知 going to pop in here with curious updates on PVCT vorlon1966 1 9/25/2020 8:55:16 PM
114856 Re: I知 going to pop in here with curious updates on PVCT Ubmmg 1 9/27/2020 12:05:15 PM






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