That's a personal decision. If I was trying to accumulate a stock , lending it out would allow it to be shorted and might help me to buy at a lower price. In fact , for tight stocks brokers would sell our institution blocks at lower prices if we agreed in advance to a stock loan on settle date.
Once I was done accumulating I'd probably not agree to lend it out especially in a name like ZIOP. There's no question the 50 mill short position is affecting the equilibrium stock price and for a company frequently needing to raise cash, a lower equilibrium price raises their cost of capital.