On May 14, 2019, a wholly-owned subsidiary of OPKO Health, Inc., Bio-Reference Laboratories, Inc., a New Jersey corporation (“BRLI”), provided notice to JPMorgan Chase Bank, N.A. (“Chase”) that BRLI elected to permanently reduce the amount of BRLI’s aggregate commitment from $175,000,000 to $100,000,000 under that certain Credit Agreement (as amended, the “Credit Agreement”), dated as of November 5, 2015, by and among BRLI, certain of its subsidiaries from time to time party thereto, the lenders from time to time party thereto and Chase, as administrative agent for the lenders. BRLI effected this election in accordance with the existing terms of the Credit Agreement, which remain in full force and effect.