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Response rates have dropped in BPDCN, there was a CR and CRi (unconfirmed) last year out of n=3, this year there was an additional PR and I assume the existing unconfirmed CRi was confirmed out of n=9.
The potential in AML seems real, particularly as the patients exhibiting responses were mostly heavily pre-treated. Another notable feature is its very good safety profile over n=95 across this long a period, which is not seen for rival CD-123 targeted cross linking agents from seattle genetics: