'435 patent stands partially valid while '127 all invalidated | ABUS Message Board Posts

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Msg  34753 of 34949  at  1/7/2020 11:21:01 PM  by

liuyiiv


 In response to msg 34752 by  liuyiiv
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Re: '435 patent stands partially valid while '127 all invalidated

valid claims:
 
7. The nucleic acid-lipid particle of claim 5, wherein the phospholipid comprises from 3 mol % to 15 mol % of the total lipid present in the particle.
8. The nucleic acid-lipid particle of claim 5, wherein the cholesterol or derivative thereof comprises from 30 mol % to 40 mol % of the total lipid present in the particle.
10. The nucleic acid-lipid particle of claim 9, wherein the PEG-lipid conjugate comprises a PEG-diacylglycerol (PEG-DAG) conjugate, a PEG-dialkyloxypropyl (PEG-DAA) conjugate, or a mixture thereof.
11. The nucleic acid-lipid particle of claim 10, wherein the PEG-DAA conjugate comprises a PEG-dimyristyloxypropyl (PEG-DMA) conjugate, a PEG-distearyloxypropyl (PEG-DSA) conjugate, or a mixture thereof.
13. The nucleic acid-lipid particle of claim 1, wherein the nucleic acid is fully encapsulated in the nucleic acid-lipid particle.
16. A method for the in vivo delivery of a nucleic acid, the method comprising:
administering to a mammalian subject a nucleic acid-lipid particle of claim 1.
17. A method for treating a disease or disorder in a mammalian subject in need thereof, the method comprising:
administering to the mammalian subject a therapeutically effective amount of a nucleic acid-lipid particle of claim 1.
18. The method of claim 17, wherein the disease or disorder is a viral infection.
19. The method of claim 17, wherein the disease or disorder is a liver disease or disorder.
20. The method of claim 17, wherein the disease or disorder is cancer.


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