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Msg  34438 of 34708  at  7/24/2018 1:35:47 PM  by

evernewbliss


 In response to msg 34436 by  jtrader87
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Re: Chime in on this

It is not really important how much dose does it take.. What is really important is the therapeutic index. Therapeutic index is the difference between the effective dose and the maximum amount of dose that can be safely delivered. Clinically tested LNP have very low therapeutic index and durability. GalNAc are durable and have therapeutic index of over 100 which is very hard to achieve with LNP. That is why they are going with GalNAc.


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Replies
Msg # Subject Author Recs Date Posted
34439 Re: Chime in on this jtrader87 0 7/24/2018 4:16:35 PM
34441 Re: Chime in on this egomaniakos 4 7/24/2018 9:28:08 PM


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