Looks like Moderna have not figured out LNP | ABUS Message Board Posts

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Msg  34234 of 34949  at  3/29/2018 9:05:59 AM  by


Looks like Moderna have not figured out LNP

But still want and need to....


Moderna is seeking a modeler with a background in coarse-grained molecular dynamics simulations to tackle challenging problems in drug product delivery and efficacy. This person will be responsible for in silico characterization and prediction of our lipid nanoparticles for drug delivery. He/she will work closely with our drug delivery group to understand mechanism of action for delivery and optimize for efficacy. This one-year contract position is based in Cambridge, MA with the option, but no guarantee, for renewal or transition to a permanent position. This position reports to the Senior Scientist in Computational Chemistry.

Here s What You ll Do:

Characterize novel lipid nanoparticles (LNPs) structures using state of the art coarse-grained molecular dynamics simulations
Correlate predicted LNP structure to function and efficacy of drug product
Discover new computational methodology, create workflows and share successful methods
Drive the development of next generation drug delivery vehicles, including LNPs and polymers
Setup, install, and maintain all necessary software packages to perform coarse-grained simulations, e.g., MARTINI and GROMACS
Collaborate with groups across the company to support research projects, including Delivery Innovation and Formulations
Apply chemistry, physics, and engineering knowledge to draw rigorous, actionable conclusions from complex data
Communicate findings internally and externally

Here s What You ll Bring to the Table:

Ph.D. and 0-2 years of experience in physical chemistry, chemical engineering, biophysics, bioengineering or related field
Extensive experience in coarse-grained molecular dynamics simulations, preferably of lipids
Proficient in at least one programming or scripting language, such as Python or Perl
Comfort working in a Linux-based High Performance Computing environment
Willingness to learn and tackle abstract problems
Comfortable operating in a rapidly-changing environment and making actionable conclusions from incomplete data
Creative problem solver able to draw conclusions from complex datasets, and present them in a clear and understandable way
Strong written and oral communication skill

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Msg # Subject Author Recs Date Posted
34235 Re: Looks like Moderna have not figured out LNP Manny 0 3/29/2018 10:32:24 AM
34238 Re: Looks like Moderna have not figured out LNP LookoutJoe 0 3/29/2018 1:50:59 PM

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