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Msg  18163 of 23533  at  4/5/2018 2:53:42 PM  by

erniewerner

The following message was updated on 4/5/2018 2:53:42 PM.

Cotezo vs Stivarga (Regor)

With all the appropriate cautions about cross trial comparisons, lets see what we have.
                                                      Cotezo
As of May 10, 2017, 84 pts (57 KRASmt, 25 KRASwt, 2 unknown) were enrolled and evaluable. 66 pts had received 5+ prior therapies; 38 had known MSI status at baseline (MSS [n = 29], MSI-low [n = 8], MSI-H [n = 1]). A + C combination was tolerable. Treatment-related Gr 1-2 and Gr 3-4 AEs occurred at 60% and 37%, respectively. The most frequent related Gr 3-4 AEs were increased blood CPK, rash, diarrhea and fatigue (5% each). No treatment-related Gr 5 AEs occurred. 13% and 24% of pts experienced AEs leading to A and C withdrawal, respectively. Median follow-up was 14.3 mo (range, 0.5-29.8). Confirmed PR was observed in 7 pts (8%; locally reported MSS [n = 3], MSI-low [n = 1], MSI unknown [n = 3]). Median DOR was 14.8 mo (95% CI: 6.0, NE); DCR (PR + SD) was 31%. Median PFS was 1.9 mo (95% CI: 1.8, 2.3); median OS was 10.0 mo (95% CI: 6.2, 14.1). The 6-mo and 1-y OS rates were 65% (95% CI: 54, 76) and 46% (95% CI: 34, 58), respectively.
                                                   Regor
The median number of prior lines of therapy for metastatic disease was 3.
 
The only statistic where Stivarga looks better is PFS, 2.0 vs 1.9 months.  That is not an unusual circumstance.  I/O tens to underperform in PFS and do better on OS.  Cotezo looks better on ORR, 8% vs 1% and OS, 10.0 vs 6.4 months.  The responses were durable and the Cotezo patients more heavily pretreated.  
 
 


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Replies
Msg # Subject Author Recs Date Posted
18164 Re: Cotezo vs Stivarga (Regor) Bibliobiftek 0 4/5/2018 4:00:39 PM






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