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Msg  25201 of 25524  at  10/26/2021 12:43:59 PM  by

pharmionphil

The following message was updated on 10/26/2021 12:44:53 PM.

Rosenberg trial

Open labelunblinded

Broad applicability-all epethilial solid tumors in play




Condition or disease Intervention/treatment Phase
Glioblastoma
Non-Small Cell Lung Cancer
Breast Cancer
Gastrointestinal/Genitourinary Cancer
Ovarian Cancer
Drug: Fludarabine
Drug: Cyclophosphamide
Drug: Aldesleukin
Biological: Sleeping Beauty Transposed PBL
Phase 2

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Study Design
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Study Type : Interventional (Clinical Trial)
Estimated Enrollment : 210 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase II Study Using the Administration of Autologous T-Cells Engineered Using the Sleeping Beauty Transposon/Transposase System to Express T-Cell Receptors Reactive Against Mutated Neoantigens in Patients With Metastatic Cancer
Estimated Study Start Date : December 7, 2021
Estimated Primary Completion Date : December 31, 2028
Estimated Study Completion Date : December 31, 2029



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