ZIOP-PGEN Fundamental & Technical Discussion Board - What would the market cap of PGEN be if the science behind the 02/25 IP Grant works out? - ZIOP-PGEN Fundamental & Technical Discussion Board - InvestorVillage


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Msg  18237 of 24959  at  6/3/2020 2:20:46 AM  by

Biotech2050


What would the market cap of PGEN be if the science behind the 02/25 IP Grant works out?

IP Grant on 02/25/2020:
 
List of diseases covered in the IP Grant above:
 
1. abattoir fever,
2. abdominal angiostrongylosis (A. costaricensis),
3. accelerated aging,
4. Achlorhydra Autoimmune Active Chronic Hepatitis,
5. Acinetobacter infections
6. Actinomycosis,
7. Acute Angle Closure Glaucoma
8. Acute Disseminated Encephalomyelitis,
9. acute granulocytic leukemia,
10. Acute hemorrhagic leukoencephalitis,
11. acute intermittent porphyria,
12. acute lymphocytic leukemia,
13. acute myelocytic leukemia,
14. acute myelogenous leukemia,
15. acute respiratory distress syndrome (ARDS),
16. acute retinal necrosis,
17. Addison's Disease,
18. adrenal carcinoma,
19. adrenal cortex carcinoma,
20. adrenoleukodystrophy,
21. African Hemorrhagic Fever,
22. African sleeping sickness,
23. Agammaglobulinemia,
24. AIDS (Acquired immune deficiency syndrome),
25. alcaptonuria,
26. Aleppo boil (in the Old World);
27. Alexander disease,
28. Alopecia areata,
29. alpha.-synucleinopathy
30. Alzheimer's disease,
31. Amebiasis, Anaplasmosis,
32. American Tick Typhus,
33. amyotrophic lateral sclerosis (ALS),
34. Amyotrophic Lateral Sclerosis,
35. Angiopoetin-1,
36. Angiostatin, or Angiopoetin-1,
37. Angiostrongylosis,
38. Angle Closure Glaucoma
39. Aniridic Glaucoma, Congenital Glaucoma,
40. Anisakiasis,
41. ankylosing spondylitis
42. Anthrax,
43. Anti-GBM/TBM Nephritis,
44. Antiphospholipid syndrome
45. Antisynthetase syndrome,
46. Aplastic Anemia,
47. Arcanobacterium haemolyticum infection,
48. Argentine hemorrhagic fever,
49. arrhythmia,
50. arterial stenosis
51. Arthritis,
52. asbestosis,
53. Ascariasis,
54. Ascaridiasis,
55. Aspergilloma,
56. Aspergillosis,
57. Aspergillosis--acute invasive,
58. asthma,
59. ataxia telangectasia,
60. ataxia,
61. atelectasis,
62. atheromatous disease,
63. atherosclerosis,
64. athletes foot,
65. Atopic allergy,
66. Atopic Dermatitis,
67. ATP Binding Casette Subfamily A Member 4,
68. atrovirus infection,
69. Autoimmune cardiomyopathy,
70. Autoimmune hemolytic anemia,
71. Autoimmune hepatitis,
72. Autoimmune inner ear disease,
73. Autoimmune lymphoproliferative syndrome,
74. Autoimmune pancreatitis,
75. Autoimmune peripheral neuropathy,
76. Autoimmune polyendocrine syndrome Types I, II, & III,
77. Autoimmune progesterone dermatitis,
78. Autoimmune thrombocytopenic purpura,
79. Autoimmune uveitis,
80. Avian infectious bronchitis,
81. Avian influenza,
82. Babesiosis,
83. Bacillary Angiomatosis,
84. Bacillary dysentery,
85. Bacillary Peliosis Hepatis,
86. Bacillus cereus infection,
87. bacterial conjunctivitis,
88. Bacterial pneumonia,
89. Bacterial vaginosis (BV),
90. Bacteroides infection,
91. Bagdad boil,
92. Balantidial dysentery,
93. Balantidiasis,
94. Balkan grippe,
95. Balkan influenza,
96. Balo concentric sclerosis,
97. Balo disease
98. Bannworth's syndrome (lime disease),
99. basophilic disorder,
100. Bauru ulcer,
101. Baylisascaris infection,
102. Bechets Syndrome,
103. BEMP,
104. Benign Epidermal Monkeypox,
105. Benign Lymphoreticulosis,
106. Benign nonbacterial Lymphadenitis,
107. Berger's disease,
108. Bickerstaffs encephalitis,
109. BK virus infection,
110. Black piedra,
111. Black Vomit,
112. bladder cancer,
113. bladder carcinoma,
114. Blastocystis hominis infection,
115. blastomycosis,
116. Blau syndrome,
117. bleeding and clotting disorders
118. Borrelia infection,
119. Botulism (and Infant botulism),
120. Bovine respiratory disease,
121. Bovine spongiform encephalopathy,
122. brain cancer,
123. Brazilian hemorrhagic fever,
124. breast cancer,
125. breast carcinoma,
126. bronchiectasis,
127. bronchiolitis obliterans organizing pneumonia (BOOP),
128. bronchitis,
129. Brucellosis, Burkholderia infection,
130. Brugiasis,
131. Bullous Pemphigoid,
132. Buruli ulcer, Calcivirus infection (Norovirus and Sapovirus),
133. California encephalitis/La crosse encephalitis,
134. Canavan disease,
135. candida balanitis,
136. candida vulvitis,
137. candidiasis (cutaneous and mucocutaneous),

138. Canine Corona Virus (CCV) or canine parvovirus enteritis,
139. Canine leishmaniasis,
140. Capillariasis,
141. cardiac insufficiency,
142. cardiogenic shock,
143. Castleman's disease,
144. Cat Scratch Fever,
145. cataracts
146. Cat-scratch disease,
147. Cellulitis,
148. Cerebral Amyloid Angiopathy,
149. cerebral palsy,
150. cervical carcinoma,
151. cervical hyperplasia,
152. Chagas Disease (American trypanosomiasis),
153. Chagas-Mazza Disease,
154. Chagas's Disease,
155. Chancroid,
156. Chicago disease,
157. Chickenpox,
158. Chiclero ulcer,
159. Chlamydia,
160. Chlamydiosis,
161. Cholera,
162. choreoathetosis
163. choriocarcinoma,
164. choroidal neovascularization,
165. Chromoblastomycosis,
166. chromomycosis,
167. Chronic Angle Closure Glaucoma,
168. Chronic Fatigue Immune Dysfunction Syndrome,
169. chronic fatigue,
170. chronic granulocytic leukemia,
171. chronic inflammatory demyelinating polyneuropathy,
172. chronic lymphocytic leukemia,
173. chronic mucocandidiasis (e.g., thrush and vaginal candidiasis),
174. chronic myelocytic leukemia,
175. chronic myelogenous leukemia,
176. Chronic recurrent multifocal ostomyelitis,
177. chronic renal failure
178. Chronic wasting disease,
179. Churg-Strauss syndrome,
180. Cicatricial Pemphigoid,
181. ciliary block glaucoma
182. Circling disease,
183. Classical swine fever,
184. Clonorchiasis,
185. closed angle glaucoma,
186. Clostridium difficile,
187. coccidioidomycosis,
188. Coeliac Disease,
189. Cogan syndrome,
190. Cold agglutinin disease,
191. Colibacteriosis,
192. colitoxemia,
193. colon cancer,
194. colon carcinoma,
195. Colorado tick fever (CTF),
196. Common cold (Acute viral rhinopharyngitis; Acute coryza),
197. Complement component 2 deficiency,
198. congenital adrenal hyperplasia,
199. congenital cystic adenomatoid malformation (CCAM),
200. congestive heart failure,
201. contagious abortion,
202. COPD (chronic obstructive pulmonary disease),
203. coronary artery disease,
204. coronary heart disease,
205. coronary insufficiency,
206. Cranial arteritis, CREST syndrome,
207. Creutzfeldt-Jakob disease (CJD),
208. Crohns Disease,
209. Cryptococcosis and histoplasmosis,
210. Cushing's Syndrome,
211. Cutaneous leishmaniasis:
212. Cutaneous leukocytoclastic angiitis,
213. cutaneous necrotizing venulitis,
214. cystic fibrosis
215. Cystic hydatid disease,
216. dairy worker fever (L. hardjo),
217. deep vein thrombosis (DVT),
218. deer-fly fever,
219. degenerative disease,
220. Dego's disease,
221. Delhi boil,
222. Dengue fever,
223. dentatorubral pallidoluysian atrophy (DRLPA).
224. Dermatitis herpetiformis,
225. Dermatomyositis,
226. Devic's Disease,
227. diabetes
228. Diabetes mellitus type 1,
229. diabetes type I,
230. diabetes type II,
231. diabetic retinopathy
232. Dientamoebiasis,
233. Diffuse cutaneous systemic sclerosis,
234. dimorphic fungus,
235. Diphtheria,
236. Diphyllobothriasis,
237. Discoid lupus erythematosus,
238. disorders of amino acid metabolism
239. disorders of carbohydrate metabolism
240. disorders of fatty acid oxidation
241. disorders of mitochondrial function
242. disorders of organic acid metabolism
243. disorders of peroxisomal function
244. disorders of porphyrin metabolism
245. disorders of purine or pyrimidine metabolism
246. disorders of steroid metabolism
247. disseminated intravascular coagulation (DIC),
248. Dracunculiasis,
249. Dressler's syndrome,
250. dyslipidemia,
251. dystonia,
252. Eales disease,
253. Ebola hemorrhagic fever,
254. Echinococcosis,
255. Echinococcus granulosis,
256. Echinococcus,
257. eczema,
258. Ehrlichiosis,
259. embolism,
260. emphysema,
261. Endemic Typhus Fever,
262. endocrine deficiencies of aging,
263. endometrial carcinoma,
264. endophthalmitis,
265. Endostatin,
266. Entamoeba histolytica,
267. enteric paratyphosis,
268. Enterococcus infection,
269. Enterovirus infection,
270. Enterobiasis (Pinworm infection),
271. Enthesitis-related arthritis,
272. Enzootic pneumonia,
273. eosinophilic disorder,
274. Eosinophilic fasciitis,
275. eosinophilic granuloma,
276. eosinophilic meningitis or meningoencephalitis (A. cantonensis),
277. eosinophilic pneumonia,
278. epidemic arthritic erythema,
279. Epidemic Hemorrhagic Fever,
280. Epidemic hepatitis,
281. Epidemic jaundice,
282. Epidemic typhus,
283. Epidermolysis bullosa acquisita,
284. epiretinal macular membranes
285. episcleritis choroidopathies
286. epizootic abortion,
287. Epstein-Barr Virus Infectious Mononucleosis (Mono),
288. erythema chronicum migrans,
289. Erythema infectiosum,
290. Erythema nodosum,
291. erythrasma,
292. esophageal carcinoma,
293. espundia,
294. Essential mixed cryoglobulinemia,
295. essential thrombocytosis,
296. Evan's syndrome,
297. Exanthem subitum,
298. Exfoliative Glaucoma,
299. Fabry's disease,
300. familial exudative vitreoretinopathy (FEVR)
301. famine fever,
302. Fasciolopsiasis,
303. Fasciolosis,
304. Fatal familial insomnia (FFI),
305. feline infectious peritonitis virus,
306. Fibrodysplasia ossificans progressiva,
307. Fibromyositis,
308. Fibrosing aveolitis,
309. Filariasis,
310. FIP,
311. Flea-borne Typhus Fever,
312. Foot-and-mouth disease,
313. Fowl Plague,
314. Francis' disease,
315. Fredrich's ataxia,
316. Frontotemporal Dementia (FTD)
317. fucosidosis,
318. fungal conjunctivitis,
319. fungal diaper rash,
320. fungemia,
321. fusariosis,
322. Fusobacterium infection,
323. G.sub.m1 gangliosidosis,
324. Gambian Trypanosomiasis,
325. gammaglobulinemia
326. Gas gangrene (Clostridial myonecrosis),
327. Gastritis,
328. Gastrointestinal pemphigoid,
329. Gaucher's disease,
330. genitourinary carcinoma,
331. Geotrichosis,
332. geotrichosis, trichosporosis,
333. Gerstmann-Straussler-Scheinker syndrome (GSS),
334. gestational diabetes,
335. Giant cell arteritis,
336. giardiasis,
337. Giardiasis Glanders,
338. Gilchrist's disease,
339. glioblastoma,
340. glioma,
341. glucose intolerance,
342. glutaric acidemia type 1,
343. glycogen storage disease,
344. Gnathostomiasis,
345. Gonorrhea,
346. Goodpasture's syndrome,
347. Granuloma inguinale (Donovanosis),
348. Graves' disease,
349. Green or Vervet Monkey Disease,
350. Group A streptococcal infection,
351. Group B streptococcal infection,
352. Guillain-Barre syndrome (GBS),
353. gut edema of swine,
354. Haemophilus influenzae,
355. Hagerman Redmouth Disease (ERMD),
356. hairy cell leukemia,
357. Hallervorden-Spatz disease,
358. Hand, foot and mouth disease (HFMD),
359. Hansen's disease,
360. Hantavirus Pulmonary Syndrome (HPS) Helicobacter pylori infection,
361. hantavirus pulmonary syndrome,
362. Hashimoto's encephalitis,
363. Hashimoto's thyroiditis,
364. Haverhill fever,
365. head or neck carcinoma,
366. head-neck cancer,
367. heart attack,
368. heart disease
369. heart failure,
370. hemochromatosis,
371. Hemolytic anaemia,
372. hemophilia,
373. Hemorrhagic fever with renal syndrome (HFRS),
374. Hemorrhagic jaundice (Leptospira icterohaemorrhagiae),
375. Hemorrhagic Nephrosonephritis,
376. hemorrhagic pancreaitis,
377. hemorrhagic septicemia,
378. Henoch-Schonlein purpura,
379. Henoch-Schonlien Purpura,
380. hepatitis A,
381. Hepatitis D, E,
382. hepatitis B,
383. hepatitis C,
384. hereditary angioedema
385. hereditary hemorrhagic telangiectasia,
386. Herpes gestationis,
387. Herpes simplex,
388. Herpesvirus simiae,
389. high blood pressure,
390. histoplasmosis,
391. Hodgkin lymphoma,
392. Hodgkin's disease,
393. Hookworm Disease,
394. Hookworm infection,
395. Hughes syndrome
396. Human ewingii ehrlichiosis,
397. Human granulocytic anaplasmosis (HGA),
398. human immune deficiency virus (HIV), hepatitis,
399. Human monocytic ehrlichiosis,
400. Human papillomavirus (HPV) infection,
401. Human parainfluenza virus infection,
402. Huntington's disease,
403. Hydatid Disease,
404. Hydatidosis,
405. Hydrophobia,
406. Hymenolepiasis,
407. hypercoagulability,
408. hyperglycemia,
409. hyperinsulinemia,
410. hyperlipidemia,
411. hypersensitivity pneumonitis,
412. hypertension,
413. hypertensive heart disease,
414. Hypogammaglobulinemia,
415. hypoxemia,
416. hypoxia,
417. ic-uremic syndrome (HUS),
418. Idiopathic Inflammatory Demyelinating Diseases,
419. idiopathic interstitial pneumonia,
420. idiopathic polypoidal choroidal vasculopathy,
421. Idiopathic pulmonary fibrosis,
422. Idiopathic thrombocytopenic purpura,
423. IgA nephropathy
424. impaired glucose tolerance,
425. Inclusion body myositis,
426. infant respiratory distress syndrome,
427. Infectious Hematopoietic necrosis (IHN),
428. Infectious hepatitis,
429. inflammation response after intra-ocular lens implantation,
430. Influenza (flu),
431. inovirus infection,
432. insulin resistance syndrome,
433. insulin resistance,
434. intertrigo,
435. ischemic cardiac events,
436. ischemic heart disease,
437. ischemic optic neuropathy
438. Isosporiasis,
439. Jaagsiekte, Maedi-Visna,
440. Jock Itch,
441. Juvenile Glaucoma,
442. Juvenile idiopathic arthritis,
443. Juvenile rheumatoid arthritis,
444. kala-azar,
445. Kaposi's sarcoma,
446. Kawasaki disease,
447. Kearns-Sayre syndrome,
448. keratic precipitates,
449. Keratitis,
450. Kernicterus
451. Kew Gardens Spotted Fever,
452. Kingella kingae infection,
453. Korean Hemorrhagic Fever,
454. Krabbe's disease,
455. Kuru,
456. Lambert-Eaton myasthenic syndrome,
457. laryngitis,
458. Lassa fever,
459. Legionellosis (Legionnaires' disease),
460. Legionellosis (Pontiac fever),
461. Leishmaniasis,
462. Lens-Induced Glaucoma,
463. Leprosy,
464. Leptospirosis,
465. Lesch-Nyhan syndrome,
466. leukemias
467. Leukocytoclastic vasculitis,
468. leukodystrophies
469. Lewy Body Disease,
470. Lichen planus,
471. Lichen sclerosus,
472. Linear IgA disease (LAD),
473. Listeriosis,
474. liver cancer,
475. Lou Gehrig's Disease,
476. Low Tension Glaucoma,
477. Lung cancer,
478. lung carcinoma,
479. lung transplantation,
480. Lupoid hepatitis,
481. Lupus erythematosus,
482. Lyme arthritis,
483. Lyme disease (Lyme borreliosis),
484. lymphangioleiomyomatosis,
485. Lymphatic filariasis (Elephantiasis),
486. Lymphocytic choriomeningitis,
487. lymphocytopenia,
488. lymphomas
489. Lyssa,
490. macroglobulinemia,
491. macular degeneration
492. macular edema
493. macular oedema
494. Majeed syndrome,
495. Malaria,
496. malignant carcinoid carcinoma,
497. malignant hypercalcemia,
498. malignant melanoma,
499. malignant pancreatic insulinoma,
500. Malta fever,
501. maple syrup urine disease
502. Marburg hemorrhagic fever (MHF),
503. mary amoebic meningoencephalitis (PAM),
504. Mastitis in animals,
505. Measles,
506. Mediterranean fever (Brucellosis) or Bang's disease or undulant fever,
507. medium chain acyl dehydrogenase deficiency,
508. melanoma,
509. Melioidosis (Whitmore's disease),
510. Meniere's disease,
511. Meningitis,
512. Meningococcal disease,
513. menorrhagia,
514. mesothelioma,
515. metabolic cardiovascular risk syndrome,
516. metabolic syndrome X
517. metachromatic leukodystrophy,
518. Metagonimiasis,
519. Microscopic polyangiitis,
520. Microsporidiosis,
521. Microsporosis,
522. Microsporum canis,
523. Mild Cognitive Impairment,
524. Miller-Fisher syndrome,
525. mitochondrial metabolism
526. Mixed Connective Tissue Disease,
527. mixed connective tissue disease,
528. MODY,
529. Molluscum contagiosum (MC),
530. monary alveolar proteinosis,
531. monoclonal gammopathies of undetermined significance,
532. monocyte disorders,
533. Morbilli,
534. Morquio-B disease,
535. movement disorders
536. Mucha-Habermann disease,
537. Muckle-Wells syndrome,
538. Multiple Myeloma,
539. multiple sclerosis (MS),
540. Multiple System Atrophy (MSA),
541. Mumps,
542. Murine typhus (Endemic typhus),
543. Myasthenia gravis,
544. Mycetoma,
545. Mycoplasma pneumonia,
546. mycosis fungoides,
547. Mycotic Dermatitis of Sheep,
548. mycotic keratitis,
549. myelodysplasia,
550. myelofibrosis,
551. myeloma,
552. myeloproliferative disorders
553. Myiasis,
554. myocardial infarction,
555. myocardial rupture,
556. Myositis, Narcolepsy,
557. n bocavirus infection,
558. narrow angle glaucoma,
559. Necatoriasis,
560. necrotizing pneumonia,
561. Neonatal conjunctivitis (Ophthalmia neonatorum),
562. Neovascular Glaucoma,
563. Nephropathia Epidemica,
564. neuroblastoma,
565. Neuromyelitis optica
566. neuronal ceroid lipofucsinoses,
567. neutropenia,
568. neutrophillic leukocytosis,
569. (New) Variant Creutzfeldt-Jakob disease (vCJD, nvCJD),
570. Newcastle disease,
571. Niemann-Pick Type C disease (NPCD),
572. Nocardiosis, Onchocerciasis (River blindness),
573. non-Hodgkin lymphoma
574. non-small cell lung cancer,
575. North American blastomycosis,
576. obesity,
577. Occular cicatricial pemphigoid,
578. occular toxoplasmosis,
579. ocular glaucomas (for example, inflammatory glaucomas),
580. Oesophagostomiasis,
581. O'Hara disease,
582. Open Angle Glaucoma
583. optic neuritis,
584. orbital pseudotumor,
585. Ord thyroiditis,
586. Orf (animal disease),
587. oriental sore,
588. Ornithosis, Parrot Fever,
589. ory demyelinating polyneuopathy,
590. osteogenic sarcoma,
591. otitis externa,
592. otitis media,
593. otomycosis,
594. ous larva migrans (CLM),
595. ovarian cancer,
596. ovarian carcinoma,
597. Palindromic rheumatism,
598. pancreatic cancer,
599. pancreatic carcinoma,
600. PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus),
601. Paracoccidioidomycosis (South American blastomycosis),
602. Paragonimiasis,
603. Paraneoplastic cerebellar degeneration,
604. Parkinsonism Disease,
605. paronychia,
606. Parry Romberg syndrome,
607. Parsonnage-Turner syndrome,
608. Pars planitis,
609. Pasteurellosis,
610. Pediculosis capitis (Head lice),
611. Pediculosis corporis (Body lice),
612. Pediculosis pubis (Pubic lice, Crab lice),
613. Pelizaeus-Merzbacher disease,
614. Pelvic inflammatory disease (PID),
615. Pemphigus vulgaris,
616. Pemphigus,
617. penicilliosis,
618. pericarditis,
619. peripheral vascular disease
620. Perivenous encephalomyelitis,
621. Pernicious anaemia,
622. Pertussis (Whooping cough),
623. Peste des petits ruminants,
624. pestilential fever,
625. pharyngitis,
626. phenylketonuria
627. pianbols,
628. Pigment Derived Growth Factor (PDGF),
629. pigment dispersion syndrome (pigmentary glaucoma),
630. Pigmentary Glaucoma,
631. Piroplasmosis, toxoplasmosis,
632. pityriasis versicolor,
633. Plague,
634. plasma cell disorders
635. Pneumococcal infection,
636. pneumoconiosis,
637. Pneumocystis pneumonia (PCP),
638. pneumocystosis,
639. pneumonia,
640. pneumorickettsiosis,
641. pneumothorax,
642. POEMS syndrome,
643. Poliomyelitis,
644. Polyarteritis nodosa,
645. polycythemia vera,
646. Polymyalgia rheumatica,
647. Polymyositis,
648. porcine Actinobacillus (Haemophilus) pleuropneumonia,
649. Porcine respiratory disease,
650. Post-Traumatic Glaucoma,
651. Pox diseases,
652. Prevotella infection,
653. Primary biliary cirrhosis,
654. primary brain carcinoma,
655. primary macroglobulinemia,
656. Primary Open Angle Glaucoma,
657. Progressive multifocal leukoencephalopathy,
658. Progressive Supranuclear Palsy,
659. proliferative vitreoretinopathy,
660. prostate cancer,
661. prostatic carcinoma,
662. pseudallescheriosis,
663. Pseudoglanders,
664. Pseudotuberculosis,
665. Psittacine beak and feather disease,
666. Psittacosis,
667. psoriasis, psoriatic arthritis,
668. psoriatic arthritis,
669. pulmonary actinomycosis,
670. pulmonary alveolar proteinosis,
671. pulmonary anthrax,
672. pulmonary arteriovenous malformation,
673. pulmonary dysfunction,
674. pulmonary edema,
675. pulmonary embolus,
676. pulmonary fibrosis,
677. Pulmonary hamartoma,
678. pulmonary hemorrhage,
679. pulmonary histiocytosis X
680. pulmonary hypertension,
681. pulmonary Langerhans' cell histiocytosis,
682. pulmonary nocardiosis,
683. pulmonary sequestration,
684. pulmonary tuberculosis,
685. pulmonary veno-occlusive disease,
686. pupillary block glaucoma,
687. pure red cell aplasia,
688. Pyoderma gangrenosum,
689. Q fever,
690. Query fever,
691. rabbit fever,
692. Rabies,
693. radiation fibrosis,
694. radiation retinopathy,
695. ral effusion,
696. Rasmussen's encephalitis,
697. Rat-bite fever,
698. Raynaud phenomenon,
699. Reaven's syndrome,
700. Reiter's syndrome,
701. Relapsing fever,
702. Relapsing polychondritis,
703. renal cell carcinoma,
704. renal failure
705. Respiratory syncytial virus infection,
706. retinal artery occlusions,
707. retinal edema,
708. retinal vascular disease
709. retinal vasculitis
710. retinal vein occlusions,
711. retinitis pigmentosa
712. retinoblastoma
713. retinopathies
714. retinopathy of prematurity,
715. Retroperitoneal fibrosis,
716. Rett Syndrome,
717. rhabdomyosarcoma,
718. Rheumatoid arthritis,
719. Rheumatoid fever,
720. rheumatoid lung disease,
721. Rhinosporidiosis,
722. Rhodesian Trypanosomiasis,
723. Rickettsial infection,
724. Rickettsialpox,
725. Rift Valley fever (RVF),
726. ringworm or tinea infections,
727. Rocky mountain spotted fever (RMSF),
728. Rotavirus infection,
729. Rubella,
730. Rubeola,
731. Salmonella food poisoning,
732. Salmonellosis,
733. Sandhoff disease,
734. sarcoidosis,
735. SARS (Severe Acute Respiratory Syndrome),
736. Scabies,
737. Schistosoma
738. Schistosomiasis,
739. Schmidt syndrome,
740. Schnitzler syndrome,
741. Scleritis,
742. scleroderma,
743. sepsis,
744. seronegative spondyloarthropathies,
745. Shigellosis (Bacillary dysentery),
746. Shingles (Herpes zoster),
747. Shipping or transport fever,
748. sickle cell disease,
749. Simian B Disease,
750. sinusitis,
751. Sjogren's syndrome,
752. skin cancer,
753. small-cell lung carcinoma,
754. Smallpox (Variola), Sporotrichosis,
755. sodoku,
756. soft-tissue sarcoma,
757. South American Trypanosomiasis,
758. Sparganosis,
759. spinocerebellar ataxia Type 1, Type 2, and Type 3,
760. spirochetal fever,
761. spleen disorders,
762. Spondyloarthropathy,
763. Sporothrix schenckii,
764. sporotrichosis,
765. Staphylococcal alimentary toxicosis,
766. Staphylococcal food poisoning,
767. staphylococcal gastroenteritis,
768. Staphylococcal infection,
769. Steroid-Induced Glaucoma,
770. sticky blood syndrome,
771. Still's Disease,
772. stomach carcinoma,
773. Streptobacillary fever,
774. Streptotrichosis,
775. stroke,
776. Strongyloidiasis,
777. Sturge-Weber Syndrome Glaucoma,
778. Subacute bacterial endocarditis (SBE),
779. Susac's syndrome,
780. Sweet syndrome,
781. Swine and Equine Influenza,
782. Sydenham Chorea,
783. Sympathetic ophthalmia,
784. syndrome X,
785. Syphilis,
786. systemic lupus erythematosus,
787. systemic necrotizing arteritis,
788. systemic sclerosis,
789. Taeniasis,
790. Takayasu's arteritis,
791. tanus (Lockjaw),
792. Tapeworm Infection,
793. Tay-Sachs disease,
794. Temporal arteritis,
795. testicular carcinoma,
796. thalassemia.
797. thermal injury
798. thrombocythemia,
799. thrombocytopenia (ITP, TTP),
800. thrombophilia,
801. thrombosis,
802. thyroid associated orbitopathy,
803. thyroid carcinoma,
804. Tick-borne fever,
805. tick-borne meningopolyneuritis,
806. tick-borne relapsing fever,
807. Tick-borne Typhus Fever,
808. Tinea barbae (Barber's itch),
809. Tinea capitis (Ringworm of the Scalp),
810. Tinea corporis (Ringworm of the Body),
811. Tinea cruris (Jock itch),
812. Tinea manuum (Ringworm of the Hand),
813. Tinea nigra,
814. Tinea unguium (Onychomycosis),
815. Tinea versicolor (Pityriasis versicolor),
816. Tinea,
817. Tolosa-Hunt syndrome,
818. tonsillitis,
819. Tourette's syndrome,
820. Toxocariasis (Visceral Larva Migrans (VLM)),
821. Toxoplasmosis,
822. transmissible gastroenteritis (TGE) virus,
823. Transverse Myelitis,
824. trauma,
825. tremor disorders,
826. Trichinosis,
827. Trichinellosis,
828. Trichomoniasis,
829. Trichuriasis (Whipworm infection),
830. Trichophytosis,
831. Trichostrongylosis,
832. Tuberculosis,
833. Tularemia,
834. Type C lethargic encephalitis,
835. Ulcerative Colitis,
836. Uncinariasis,
837. Undifferentiated connective tissue disease,
838. Undifferentiated spondyloarthropathy,
839. Urban Typhus,
840. Ureaplasma urealyticum infection,
841. uta, and buba (in the Americas);
842. uveitis syndromes (for example, chronic iridocyclitis or chronic endophthalmitis),
843. uveitis,
844. Uveitis-Induced Glaucoma,
845. vagabond fever,
846. vascular leak in the subject
847. vasculitis,
848. Venezuelan equine encephalitis,
849. Venezuelan hemorrhagic fever,
850. Vesicular Rickettsiosis,
851. Vibriosis,
852. viral conjunctivitis,
853. viral pneumonia,
854. Visceral leishmaniasis:
855. Vogt Koyanaki Harada syndrome,
856. Von Willebrand's disease,
857. Wegener's granulomatosis,
858. Weil's disease (Leptospirosis) or canicola fever,
859. West Nile Fever,
860. wet and dry age-related macular degeneration,
861. white blood cell disorders
862. White piedra (Tinea blanca),
863. white scours,
864. Whitmore's disease,
865. Wilms' tumor,
866. Wilson's syndrome,
867. Wiskott-Aldrich syndrome
868. Yellow fever,
869. Yersinia pseudotuberculosis infection,
870. Yersiniosis,
871. Zellweger syndrome
872. Zygomycosis
Included in the invention above is:  
 
In another aspect, the present disclosure provides a method of controlling, e.g., reducing or preventing the spread of, or killing, insects comprising contacting the insects or their habitat with an insecticidally effective amount of a Compound of the Disclosure, or a composition thereof. In another embodiment, Compounds of the Disclosure, or a composition thereof, are insecticidally active against:
(1) insects from the order of the lepidopterans (Lepidoptera), for example, Agrolis ypsilon, Agrotis segetum, Alabama argillacea, Anficarsia gemmalalis, Argyresthia conjugella, Autographa gamma, Bupalus piniarius, Cacoecia murinana, Capua reticulana, Cheimatobia brumata, Choristoneura fumiferana, Choristoneura occidentalis, Cirphis unipuncta, Cydia pomonella, Dendrolimus pini, Diaphania nitidalls, Dlatraea grandiosella, Earias insulana, Elasmopalpus lignosellus, Eupoecilia ambiguella, Evetria bouliana, Feltia subterranea, Galleria mellonella, Grapholitha funebrana, Grapholitha molesta, Hellothis armigera, Hellothis virescens, Heliothis zea, Hellula undalis, Hibernia defoliaria, Hyphantria cunea, Hyponomeuta malinellus, Keiferia lycopersicella, Lambdina fiscellaria, Laphygma exlgua, Leucoptera coffeella, Leucoptera scitella, Lithocolletis blancardella, Lobesia botrana, Loxostege sticticalis, Lymantria dispar, Lymantria monacha, Lyonetia clerkella, Malacosoma neustria, Mamestra brassicae, Orgyia pseudotsugata, Ostrinia nubilalls, Panolls flammea, Pectinophora gossypiella, Peridroma saucia, Phalera bucephala, Phthorimaea operculella, Phyllocnistis citrella, Pieris brassicae, Plathypena scabra, Plutella xylostella, Pseudoplusia includens, Rhyacionia frustrana, Scrobipalpula absoluta, Sitotroga cerealella, Sparganothis pilleriana, Spodoptera fruglperda, Spodoptera littoralls. Spodoptera litura, Thaumatopoea pityocampa, Tortrix viridana, Trichoplusia ni and Zeiraphera Canadensis;
(2) beetles (Coleoptera), for example, Agrilus sinuatus, Agriotes lineatus, Agriotes obscurus, Amphimallus solstitialis, Anisandrus dispar, Anthonomus grandis, Anthonomus pomorum, Aphthona euphoridae, Athous haemorrholdals, Atomaria linearis, Blastophagus piniperda, Blitophaga undata, Bruchus rujimanus, Bruchus pisorum, Bruchus lentis, Byctiscus betulae, Cassida nebulosa, Cerotoma trifurcata, Cetonia aurata, Ceuthorrhynchus assimilis, Ceuthorrhynchus napt, Chaetocnema tibialis, Conoderus vespertinus, Crioceris asparagi, Ctenicera ssp., Diabrotica longicornis, Diabrotica semipunctata, Diabrotica 12-punctata Diabrotica speciosa, Diabrotica virgifera, Epilachna varivestis, Epitrix hiirtpennis, Eutinobothrus brasiilensis, Hyloblus abietis, Hypera brunneipennis, Hypera postica, Ips typographus, Lema bilineata, Lema melanopus, Leptinotarsa decemlineata, Limonius californicus, Lissorhoptrus oryzophilus. Melanotus communis, Meligethes aeneus, Melolontha hippocastani, Melolontha melolontha, Oulema oryzae. Otiorrhynchus sulcatus, Otiorrhynchus ovatus, Phaedon cochleariae, Phyllobius pyri, Phyllotreta chrysocephala, Phyllophaga sp., Phyllopertha horticola, Phyllotreta nemorum, Phyllotreta striolala, Popillia japonica. Sitona lineatus and Sitophilus granaria;
(3) flies, mosquitoes (Diptera), for example, Aedes aegypt, Aedes albopictus, Aedes vexans, Anastrepha ludens, Anopheles maculipennis, Anopheles crucians, Anopheles albimanus, Anopheles gambiae, Anopheles freeborni, Anopheles leucosphyrus, Anopheles minimus, Anopheles quadrimaculatus, Calliphora vicina, Ceralilis capitata, Chrysomya bezziana, Chrysomya hominivorax. Chrysomya macellaria, Chrysops discails, Chrysops silacea, Chrysops allanticus, Cochliomyla hominivorax, Contarinia sorghicola Cordylobia anthropophaga, Cuhcoides furens, Culex pipiens, Culex nigripalpus, Culex quinqueasciatus, Culex tarsalis. Culiseta inornata. Culiseta melanura, Dacus cucurbitae. Dacus oleae, Dasineura brassicae, Delia antique, Delia coarctata, Delia platura, Della radicum, Dermatobia hominis, Fannia canicularis. Geomyza Tripunciata. Gasterophilus inteslinalis, Glossina morsifians, Glossina palpalis, Glossina fuscipes, Glossina tachinoides, Haematobia irritans, Haplodiplosis equestris, Hippelates spp., Hylemyia platura, Hypoderma lineata, Leptoconops torrens. Liriomyza sativae, Liriomyza triblii, Lucilia caprina, Lucilia cuprina, Lucilla sericata, Lycoria pectoralis, Mansonia titillanus, Mayetiola destructor, Musca domestlca, Muscina stabulans, Oestrus ovis, Opomyza florum, Oscinella frit, Pegomya hysocyami, Phorbia antiqua, Phorbia brassicae, Phorbia coarctata, Phlebotomus argentipes, Psorophora columbiae, Psila rosae, Psorophora discolor, Prosimullum mixtum, Rhagoletis cerasi, Rhagoletis pomonella, Sarcophaga haemorrhoidalis, Sarcophaga sp., Simulium vittatum, Stomoxys calcitrans, Tabanus bovinus, Tabanus atratus, Tabanus lineola, and Tabanus similis, Tipula oleracea, and Tipulapaludosa:
(4) thrips (Thysanoptera), for example, Dichromothrips corbetti. Dichromothrips ssp, Frankliniella fusca, Frankllniella occidentalls, Frankllniella tritici, Scirtothrlps citri, Thrips olyzae, Thrips palmi and Thrips labaci.
(5) termites (Isoptera), for example, Calotermes flavicollis, Leucotermes flavipes, Heterotermes aureus, Reticulltermes flavipes, Retfculltermes virginicus, Reticulltermes lucifugus, Termes natalensis, and Coptotermes formosanus.
(6) cockroaches (Blattaria-Blattodea), for example, Blattella germanica, Blattella asahinae, Periplaneta americana, Periplaneta japonica, Periplaneta brunnea, Periplaneta fudigginosa, Periplanela ausiralasiae, and Blatta orienltalis;
(7) true bugs (Hemiptera), for example, Acrosternum hilare, Blissus leucopterus, Cyrtopeltis notatus, Dysdercus cingulatus, Dysdercus intermedius, Eurygaster integriceps, Euschistus impictivenfris, Leptoglossus phvllopus, Lygus llneolaris, Lygus pratensis, Nezara viriduia, Piesma quadrata, Solubea insularis, Thyanta perditor, Acyrthosiphon onobrychis, Adelges laricis, Aphidula nasturti; Aphis fabae, Aphis forbesi, Aphis pomi. Aphis gossypii, Aphis grossulariae, Aphis schneideri. Aphis spiraecola, Aphis sambuci. Acyrthosiphon pisum, Aulacofthum solani, Bemisia argentifolii, Brachycaudus cardui, Brachycaudus helichrysi, Brachycaudus persicae, Brachycaudus prunicola, Brevicoryne brassicae, Capiftophorus horni, Cerosipha gossypii, Chaetosiphon fragaefolii, Cryptomyzus ribis, Dreyfusia nordmannianae, Dreyfusia piceae, Dysaphis radicola, Dysaulacorthum pseudosolani, Dysaphis plantaginea, Dysaphis pyri, Empoasca fabae, Hyalopierus pruni, Hyperomyzus laclucae, Macrosiphum avenae, Macrosiphum euphorbiae, Macrosiphon rosae, Megoura viciae, Melanaphis pyrarius, Metopolophium dirhodum, Mvzus persicae, Myzus ascalonicus, Myzus cerasi, Myzus varians, Nasonovia ribis-nigri, Nilaparvata lugens, Pemphigus bursarius, Perkinsiella saccharicida, Phorodon humuli, Psylla mall, Psylla piri, Rhopalomyzus ascalonicus, Rhopalosiphum maidis, Rhopalosiphum padi, Rhopalosiphum inserfum, Sappaphis mala, Sappaphis mali, Schizaphis graminum, Schizoneura lanuginosa, Sitobion avenae, Trialeurodes vaporariorum, Toxoptera aurantiiand, Viteus vitifolh, Cimex lectularius, Cimex hemipterus, Reduvius senilis, Triatoma spp., and Arilus critatus;
(8) ants, bees, wasps, sawflies (Hymenoptera), for example, Athalia rosae, Atta cephalotes, Atta capiguara, Atta cephalotes, Afta laevigata, Atta robusta, Atta sexdens, Atta texana, Crematogaster spp., Hoplocampa minuta, Hoplocampa testudinea, Monomorium pharaonIs, Solenopsis geminata, Solenopsis invicta, Solenopsis richteri, Solenopsis xyloni, Pogonomyrmex barbatus, Pogonomyrmex californicus. Pheidole megacephala, Dasymutilla occidentalis, Bombus spp. Vespula squamosa, Paravespula vulgaris, Paravespula pennsylvanica, Paravespula germanica, Dolichovespula maculata, Vespa crabro, Polistes rubiginosa, Camponotus floridanus and Linepithema humile;
(9) crickets, grasshoppers, locusts (Orthoptera), for example, Acheta domestica, Gryllotalpa gryllotalpa, Locusta migratoria, Melanoplus bivittatus, Melanoplus femurrubrum, Melanoplus mexicanus, Melanoplus sanguinipes, Melanoplus sprelus, Nomadacris septemfasciata, Schistocerca americans, Schistocerca gregaria, Dociostaurus maroccanus, Tachycines asynamorus, Oedaleus senegalensis, Zonozerus variegatus. Hieroglyphus daganensis, Kraussaria angulifera, Calliptamus itallcus, Chortoicetes terminifera, and Locustana pardalina;
(10) Arachnoidea, such as arachnids (Acarina), for example, of the families Argasidae, Ixodidae and Sarcoptidae, such as Amblyomma americanum, Amblyomma variegatum, Ambryomma maculatum, Argas persicus, Boophilus annulatus. Boophilus decoloratus, Boophilus microplus, Dermacentor silvarum, Dermacentor andersoni, Dermacentor variabllis, Hyalomma truncatum, Ixodes ricinus, Ixodes rubicundus. Ixodes scapularis, Ixodes holocyclus, Ixodes pacificus, Ornithodorus moubata, Ornithodorus hermsi, Ornithodorus turicata, Ornithonyssus bacoti, Otobius megnini, Dermanyssus gallinae, Psoropies ovis, Rhipicephalus sanguineus, Rhipicephalus appendiculatus, Rhipicephalus evertsi, Sarcoptes scabiei, and Eriophyidae spp. such as Aculus schlechtendali, Phyllocoptrata oleivora and Eriophyes sheldoni, Tarsonemidae spp. such as Phytonemus pallidus and Polyphagotarsonemus latus; Tenuipalpidae spp. such as Brevipalpus phoenicis; Tetranychidae spp. such as Tetranychus cinnabarinus, Tetranychus kanzawa, Tetranychus pacificus, Tetranychus telarius and Tetranychus urticae, Panonychus ulmi, Panonychus citri, and Oligonychus pratensis; Araneida, e.g., Lafrodectus mactans, and Loxosceles reclusa.
(11) fleas (Siphonaptera), for example, Ctenocephalides felis, Ctenocephahdes canis, Xenopsylla cheopis, Pulex irriftans, Tunga penefrans, and Nosopsyllus fasciatus;
(12) silverfish, firebrat (Thysanura), for example, Lepisma saccharins and Thermobia domestics:
(13) centipedes (Chilopoda), for example, Scutigera coleoptrata,
(14) millipedes (Diplopoda), for example, Narceus spp.,
(15) Earwigs (Dermaptera), for example, forifcula auricularia; and/or
(16) lice (Phthiraptera), for example, Pediculus humanus capitis. Pediculus humanus corporis, Pthirus pubis, Haematopinus eurysternus, Haematopinus suis, Linognathus vituli, Bovicola bovis, Menopon gallinae, Menacanthus stramineus and Solenopotes capillatus.
In another embodiment, Compounds of the Disclosure, or compositions thereof, are insecticidally active against insects of the order Diptera, Hemiptera, and/or Lepidoptera. In another embodiment, Compounds of the Disclosure, or a composition thereof, are insecticidally active against insects of the order Lepidoptera. In another embodiment, Compound of the Disclosures, or a composition thereof, are insecticidally active against insects of the order Hemiptera.


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