To make all tumors respond to anti-pdl1 drugs they first have to have the primer starter fire....the bigger the better. Hot enough to overcome the Treg threshold. That means the immune system sees the not me tumor and produces the chemokines which causes all cells to raise up the ligands which then the anti-pdl1 drugs would give the immune system that window to keep the fire going and get bigger and make the tumor hot....breaking tolerance. They need PV-10 first.
When you say "the bigger the better" do you mean it is better if the ablation is bigger...…... such as, perhaps using enough PV-10 to make a bigger impact/ablation?
Is it something a human can do to make it "bigger"?
Or is it how the body responds that makes it "bigger"?
And is it more about the size of a tumor?
Such as it can be "bigger" when a tumor size is big enough to allow the cellular processes to grab ahold of PV-10, and become a bigger ablation fire?
Do I recall you saying some where in the past, that a big enough tumor size can be helpful vs. too tiny?