ARNA Discussion Board - Is this the real life? Is this just fantasy? - ARNA Discussion Board - InvestorVillage
ARNA Discussion Board

  • Important Upgrade Notice: 

    At 9 pm Central, Sunday 2/16/2020, we launched the following tools as Phase One of our Premium Plus service (full service package still under development): 

    1) Customizable Scrolling Ticker
    2) Portfolio Manager
    3) Stock-specific News & Trading Email Alert Notifications

    These products are immediately available to Precious Metal & Gemstone Patrons. 

    To watch a tutorial on the "regular" site, click here. On "premium," click here

This is a semi-private group. You are free to browse messages, but you must be a member of this group to post messages. Join This Group

Group: ARNA Discussion Board   /  Message Board  /  Read Message


Rec'd By
Authored By
Minimum Recs
Previous Message  Next Message   Post Message   Post a Reply return to message boardtop of board
Msg  41018 of 49527  at  5/16/2019 1:16:46 PM  by


 In response to msg 41012 by  giannmi
view thread

Re: Is this the real life? Is this just fantasy?

Disclosure: I am in IT, so the following is just my amateur understanding of a mass balance study.  A labeled* sample of the drug is given to the subject.  Almost everything that comes out of the subject is collected.  When substantially all of the label is collected the study is over.
Assuming that the drug was labeled correctly, the collected material will have any non  metabolized drug and it's metabolites.  Almost all of the collected material will be metabolites.  Without any analysis you know the drug and its metabolites life span in the subject.  I assume that using mass cytometry or other techniques will separate the different metabolites.  If the drug has any unexpected activity or extended action, the metabolites can be tested for activity.
Going into the mass balance study, all of the data that Arena had shared showed that there was no unexpected activity.  That is unlike other drugs in the same class.
I agree that the mass balance study has reduced the risk.  I just thought the other data showed that the risk of a long lived metabolites was near zero.  I think I was right about that.  It looks like I was wrong thinking other investors had the same opinion.
* The label is a radioactive tag.   Not sure way a lanthanide tag would not work as well?

     e-mail to a friend      printer-friendly     add to library      
| More
Recs: 3     Views: 230
Previous Message  Next Message   Post Message   Post a Reply return to message boardtop of board

About Us  •  Contact Us  •  Follow Us on Twitter  •  Members Directory  •  Help Center  •  Advertise
Not a member yet? What are you waiting for? Create Account
Want to contribute? Support InvestorVillage by donating
© 2003-2019 All rights reserved. User Agreement
Financial Market Data provided by