Well we know FenPhen worked exceptionally well. We know Belviq is similar in many ways to Fenfluramine. The fact that it is more targeted to the part of the hypothalamus that regulates moods like craving and impulsiveness (and not the heart) may make it even more suited to combination with Phentermine.

Yes it needs to be tried out. "tested" may be too strong a word, it is unlikely that ARNA will do any phentermine combo testing anytime soon IMO. But it probably will be tried in the field the very first day that Belviq becomes available. It is unlikely IMO that this combo is going to cause immediate and horrible side effects, though long term we may not know for years to come if at all. But if doctors don't go full throttle here and cycle phentermine on and off a Belviq regimen, and it works well, you can bet your bottom dollar that it will spawn a cottage industry of weight loss clinics... Especially since strip mall rents are at 20 year lows.

As for BMI issues, BMI 27 is not "fat" neither is BMI 30. A 6 foot tall man 225lbs is BMI of 31. A woman 5 ft 6 who is 175 is BMI 27. There are a lot of women and men on label who qualifies. And as for doctors going off label, well think it through. Is Phentermine going to be perceived the more radical or more mild approach? But for sme reason Phentermine has the more mild label. This sort of perception inversion will probably enable doctors to rationalize the off label use...especially since the drug is likely to have little to no insurance coverage. Just my opinions. Good luck.