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Re: Medical Research Institute Has Years of Ebola Drug Expertise - DOD news 10-30-14Dr, Mysterio - perhaps you missed this? Still stand by my comment of "no mention of Sarepta". Partial snippet from DOD article. Investigating all therapeutic options In the meantime, Warren said, USAMRIID is investigating all therapeutic options to counteract Ebola virus. “We have a number of high-profile products that have been discussed in the media, and we are further investigating whether or not they can and should be used in the context of this current crisis,” he said. Especially over the past three months, he noted, organizations have approached USAMRIID about potential products they want to explore, and the institute is looking into every one. One product USAMRIID helped to develop is in Phase 1 clinical trials: TKM-Ebola, an Ebola antiviral drug from a company called Tekmira. Tekmira conducted studies on the drug in 2010 to 2013 with USAMRIID, and the DoD Joint Project Manager Transformational Medical Technologies Office, now called Medical Countermeasures Systems, contributed to funding. In 2010, Tekmira signed a $140 million contract with DoD to advance an RNA-interference, or RNAi, drug designed to eliminate the production of disease-causing proteins. The drug uses Tekmira’s lipid nanoparticle, or LPN, technology to deliver the Ebola drug to tissues in the body. In 2013, the collaboration expanded to include advances in LNP formulation technology, and in March, the FDA granted Tekmira a fast-track designation to develop the TKM-Ebola antiviral. “Tekmira is one therapeutic [for which] the product supply is the primary missing factor, and there are some questions about human safety as well,” Warren said. “But we have been working with Tekmira for many years and have already demonstrated the product’s efficacy.” Product supplies are a problem for another drug called ZMapp from Mapp Biopharmaceuticals, he added. “We have a study going on right now with ZMapp in nonhuman primates, and we've been doing ZMapp studies with earlier versions of ZMapp for years here at USAMRIID,” Dye said. |
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Msg # | Subject | Author | Recs | Date Posted |
10527 | Re: Medical Research Institute Has Years of Ebola Drug Expertise - DOD news 10-30-14 | timozark | 0 | 10/31/2014 8:59:30 AM |