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Re: playing devil's advocate!!!
We all expect clinical trial data to eventually come out and be positive. What if the data is not clinically significant?
Atkaks,
The video below was from a participant in the human clinical trials. After she reported on her personal experiences, Dr. Wilson talks to the reporter about coordinating the human trial in Michigan...and he states that the participants showed "a marked response". I take it from that specific comment that most (if not all), had positive benefits from taking Anatabloc. This trial included blood lab work, so we should eventually get actual data on key inflammatory markers (like the drop in CRP levels) in the final report.
We have had our own trials (albeit not organized double blind studies monitored by a doctor) going on right here. Here are a few of the testimonials that have been posted on this board....
I personally know about three dozen people who have taken Anatabloc, and all but two have reported positive benefits (some have reported numerous positive benefits). I'm sure it won't help everybody, but it helps a lot. These positive reports are not a simple placebo effect, because I know of several people (myself included), who have their symptoms return when not taking Anatabloc for several days.
At present, all we know is that Anatabloc does assist in preventing the NF-kB inflammation process from going haywire in the body. So, in theory, any human disease condition caused by excess NF-kB inflammation could be helped by Anatabloc. In case you are interested, here are a few human diseases where NF-kB inflammation plays a role.
excerpts....
DiseasesNF-kB DISEASES On this page are listed several diseases in which activation of NF-kB has been implicated. For general reviews on the role of NF-kB in disease, see Aradhya & Nelson (2001), Kumar et al (2004), Yamamoto & Gaynor (2002) or Baldwin (2001). For specific diseases see the listed references, which can be found either on this site (under References) or at PubMed (through the linked references). Table 1: General Diseases Disease Review/Paper Ageing Chung et al, 2002; Adler et al, 2007; Csizar et al, 2008 Allergies Cousins et al, 2008 Headaches Reuter et al, 2003 Pain Tegeder et al, 2004; Niederberger & Geisslinger, 2008 Complex Regional Pain Syndrome Hettne et al, 2007 Cardiac Hypertrophy Purcell & Molkentin, 2003; Freund et al, 2005; Sen & Roy, 2005 Muscular Dystrophy (type 2A) Baghdiguian et al, 1999 Muscle wasting Hasselgren, 2007 Catabolic disorders Holmes-McNary, 2002 Diabetes mellitus, Type 1 Ho & Bray, 1999; Eldor et al, 2006 Diabetes mellitus, Type 2 Yuan et al, 2001; Lehrke et al, 2004; Chen, 2005 Obesity Gil et al, 2007 Fetal Growth Retardation Mammon et al, 2005 Hypercholesterolemia Wilson et al, 2000 Atherosclerosis Ross et al, 2001 ; Li & Gao, 2005 Heart Disease Valen et al, 2001 Chronic Heart Failure Frantz et al, 2003; Gong et al, 2007 Ischemia/reperfusion Toledo-Pereyra et al, 2004; Nichols, 2004; Ridder & Schwaninger, 2008 Stroke Herrmann et al, 2005 Cerebral aneurysm Aoki et al, 2007; 2009 Angina Pectoris Ritchie, 1998 Pulmonary Disease Christman et al, 2000 Cystic Fibrosis Pollard et al, 2005; Carrabino et al, 2006; Rottner et al, 2007 Acid-induced Lung Injury Madjdpour et al, 2003 Pulmonary hypertension Sawada et al, 2007 Chronic Obstructive Pulmonary Disease (COPD) Barnes, 2002 ; Rahman & Kilty, 2006 Hyaline Membrane Disease Cheah et al, 2005 Kidney Disease Guijarro & Egido, 2001; Camici, 2006; Guzik & Harrison, 2007 Glomerular Disease Zheng et al, 2005 Alcoholic Liver Disease Zima & Kalousova, 2005 Leptospirosis renal disease Yang et al, 2001 Gut Diseases Neurath et al, 1998 Peritoneal endometriosis Gonzalez-Ramos et al, 2007 Skin Diseaes Bell et al, 2003 Nasal sinusitis Xu et al, 2006 Anhidrotic Ecodermal Dysplasia-ID Puel et al, 2005 Behcet’s Disease Todaro et al, 2005 Incontinentia pigmenti Courtois & Israel, 2000 Tuberculosis Zea et al, 2006 Asthma Pahl & Szelenyi, 2002 Arthritis Roshak et al, 2002 ; Roman-Blas & Jimenez, 2006; Aud & Peng, 2006; Okamoto, 2006 Crohn’s Disease Pena & Penate, 2002 Colitis (rat) Chen et al, 2005 Ocular Allergy Bielory et al, 2002 Glaucoma Zhou et al, 2005 Appendicitis Pennington et al, 2000 Paget’s Disease Lin et al, 2007 Pancreatitis Weber & Adler, 2001 ; Gray et al, 2006 Periodonitis Nichols et al, 2001; Ambili et al, 2005 Endometriosis Guo, 2006; Celik et al, 2008 Inflammatory Bowel Disease Dijkstra et al, 2002; Atreya et al, 2008 Inflammatory Lung Disease Park & Christman, 2006 Sepsis Wratten et al, 2001; Abraham, 2003 Silica-induced Chen & Shi, 2002 Sleep apnoea Lavie, 2003 AIDS (HIV-1) Hiscott et al., 2001 Autoimmunity Hayashi & Faustman, 2000; Bacher & Schmitz, 2004 Antiphospholipid Syndrome Lopez-Pedrera et al, 2005 Lupus Kammer & Tsokos, 2002 ; Okamoto, 2006; Oikonomidou et al, 2007 Lupus nephritis Zheng et al, 2006, 2008 Chronic Disease Syndrome Maes et al, 2007 Familial Mediterranean Fever Onen, 2005 Hereditary Periodic Fever Syndrome Jeru et al, 2008 Psychosocial stress diseases Bierhaus et al, 2004 Neuropathological Diseases Cechetto, 2001; Mattson & Camandola, 2001; Pizzi & Spano, 2006 Familial amyloidotic polyneuropathy, inflamm neuropathy Mazzeo et al, 2004 Traumatic brain injury Hang et al, 2005 Spinal cord injury Brambilla et al, 2005 Parkinson Disease Soos et al, 2004, Mogi et al, 2006 Multiple Sclerosis Satoh et al, 2007 Rheumatic Disease Okamoto, 2006; Greetham et al, 2007 Alzheimers Disease Mattson & Camandola, 2001; Collister & Albensi, 2005 Amyotropic lateral sclerosis Xu et al, 2006 Huntington’s Disease Khoshnan et al, 2004 Retinal Disease Kitaoka et al, 2004 Cataracts Yang et al, 2006 Hearing loss Merchant et al, 2005; Lang et al, 2006 Cancer Gilmore et al, 2002; Karin et al, 2002: Lee et al, 2007 (see Table 2, below) ______________________________________________________________________ . Table 2: Constitutive activation of NF-kB in human cancer cells Cancer type Reference A: Primary tumors and tumor cell lines Solid tumors (generally) Pacifico & Leonardi, 2006 Breast Nakshatri et al, 1997; Sovak et al, 1997; Ahmed et al, 2006 Cervix Nair et al, 2003; Kumar et al, 2005; Shehata, 2005; Ramdass et al, 2006 Ovary Dejardin et al, 1999; Huang et al, 2000 Vulva Seppanen & Vihko, 2000 Prostate Huang et al, 2001; Palayoor et al, 1999; Fradet et al, 2004; Lessard et al, 2006; Paule et al, 2007 Bladder Horiguchi et al, 2003; Kadhim et al, 2006; Levidou et al, 2008 Lung Tichelaar et al, 2004; Tang et al, 2006; Zhang et al, 2007; Motadi et al, 2007; Stathopoulos et al, 2008 Mesothelioma Bertino et al, 2007; Carbone & Bedrossian, 2006 Non small-cell lung Zhang et al, 2006; Tew et al, 2007; Jin et al, 2008 Liver Tai et al, 2000, Arsura & Cavin, 2005; Qiao et al, 2006; Seki & Brenner, 2007 Pancreas Wang et al, 1999; Sclabas et al, 2003; Xiong, 2004; Jackson & Evers, 2006; Zhang & Rigas, 2006; Sarkar et al, 2006; Weichert et al, 2007; Sebens et al, 2008; Holcomb et al, 2008 Esophageal/gastric Sutter et al, 2004; Lee et al, 2005; Abdel-Latif et al, 2005, 2008; Jackson & Evers, 2006: Levidou et al, 2007 Laryngeal Zhu et al, 2004; Pan et al, 2005 Stomach Sasaki et al, 2001; Wu et al, 2007 Colon Lind et al, 2001; Schottelius & Dinter, 2006; Aranha et al, 2007 Thyroid Visconti et al, 1997; Pacifico et al, 2004; Gombos et al, 2007 Parathyroid Corbetta et al, 2004 Melanoma Yang & Richmond, 2001; Torabian & Kashani-Sabet, 2005; Amiri & Richmond, 2005; Ueda & Richmond, 2006; Van den Oord et al, 2007 Squamous cell carcinoma Loercher et al, 2004; Kobielak & Fuchs, 2006 Head and neck Ondrey et al, 1999; Chung et al, 2006; Allen et al, 2007; Jackson-Bernitsas et al, 2007 Endometrial (Uteris) Pallares et al, 2004; Domenyuk et al, 2007 Cylindromatosis Kovalenko et al, 2003; Brummelkamp et al, 2003; Trompouki et al, 2003 Brooke-Spiegler, Trichoepithelioma Almeida et al, 2007 Hilar Cholangiocarcinoma Chen et al, 2005 Oral carcinoma Nakayama et al, 2001; Bindhu et al, 2006; Mishra et al, 2006; Sawhney et al, 2007 Min et al, 2007 Astrocytoma/glioblastoma Hayahsi et al, 2001; Garkavtsev et al, 2004 Neuroblastoma Bian et al, 2002; Brown et al, 2007; Widera et al, 2007 Glioblastoma Raychaudhuri et al, 2007; Smith et al, 2007 Hodgkin’s lymphoma Bargou et al, 1996, 1997; Staudt, 2000 Acute lymphoblastic leukemia Kordes et al, 2000; Munzert et al, 2004 Acute myelogenous leukemia Guzman et al, 2001; Fabre et al, 2007 Acute T-cell leukemia (+/-HTLV-1) Arima & Tei, 2001; Horie et al, 2006 Acute Non-lymphocytic leukemia Lei & Zhao, 2007 Chronic lymphocytic leukemia Furman et al, 2000 ; Pickering et al, 2006; Herwamana et al, 2008 Burkitts Lymphoma (EBV) Knecht et al, 2001 Mantle cell lymphoma Martinez et al, 2003 Myelodysplastic syndrome Fabre et al, 2007 Multiple myeloma Berenson et al, 2001; Gilmore, 2007 Diffuse large B-cell lymphoma Davis et al, 2001; Shaffer et al, 2002 MALT lymphoma Sagaert al, 2007; Inagaki, 2007; Du, 2007 Waldenstrom macroglobulinemia Leleu et al, 2008 B: In vitro transformation of cells AP12/MALT1 Stoffel et al, 2004; Ho et al, 2005; Lucas et al, 2007 BCR-ABL Reuther et al, 1999 BRAF Liu et al, 2007 DBL/DBS Whitehead et al, 1999 Muc1 Ahmad et al, 2007 Notch1 Vilimas et al, 2006 Pim-2 Fox et al, 2003; Hammerman et al, 2004 PDGF-beta chain Shimamura et al, 2002 RAF Baumann et al, 2000 RAS Finco et al, 1997 RET/PTC3 Russell et al, 2003 TEL-JAK2 Santos et al, 2001 TEL-PDGFR Besancon et al, 1998 Tio (herpesvirus) Heinemann et al, 2006 Vav Palmby et al, 2004 ---------------------------------------------------------------------------------------------
NJ
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| Msg # | Subject | Author | Recs | Date Posted |
| 1470 | Re: playing devil's advocate!!!// NSAID? | tivonomo | 2 | 12/27/2011 9:30:26 AM |
| 1471 | Re: playing devil's advocate!!! --- A placebo effect? | longtimelong | 12/27/2011 9:48:26 AM | |
| 1472 | Nuke, you can add this to your list | Patc | 3 | 12/27/2011 9:48:40 AM |
