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Re: Time to partner or perish(Allogenic T Cells)I see no claim on the part of NCI, Kite, Novartis, juno, or Blue that they are working on an allogenic T Cell treatment. UT and SGMO have press released it through the use of ZF's. Cellectis and Pfizer have press released it through the use of TALs. ZIOP has announced that being allogenic is an important feature od a T Cell treatment but seems focused on an oral switch to stop a cytokine storm. SGMO and UT are on "off the shelf Car T's." SGMO has also made the following patent claims on TCR's In 68159, JBWIN presented SGMO’s patent app for modifying TCR genes. Modifying TCR genes is how Adoptive Immunotherapy is done. My 68199 shows examples of the miracles Adoptive Immunotherapy can perform.
SGMO’s app states that current TCR modification suffers from: 1)native TCRs interfering with the modified TCRs 2) , unregulated and unpredictable insertion of the TCR transgene expression cassette into the genome, often at a low level. 3)Requiring Cyclophosphamide etc. to knock out native T Cells and their TCRs in order to make way for the modified ones.
SGMO claims to fix these short comings thru the use of ZFNs or Talens or CRISPrs. Their concept is that they will use one of these three to knock out receptors from the native TCR and a second one to properly insert the modified receptor on the new TCR. SGMO claims that this method fixes all three of the above noted problems.
SGMO claims examples of cancers that can be treated and/or prevented include lung carcinomas, pancreatic cancers, liver cancers, bone cancers, breast cancers, colorectal cancers, leukemias, ovarian cancers, lymphomas, brain cancers and the like.
This will be the heart of cancer therapy in the future. It appears to me that SGMO has plenty of T Cell to partner and I am just trying to figure out where the rest of the field is and how likely it is that SGMO can partner this and have it become a product rather than a patent. |
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Msg # | Subject | Author | Recs | Date Posted |
69990 | Re: Time to partner or perish(Allogenic T Cells) | MineMan | 0 | 12/21/2014 6:57:54 PM |